Eczema and Sensitization to Common Allergens in the United States: A Multiethnic, Population-Based Study
Eczema and Sensitization to Common Allergens in the United States: A Multiethnic, Population-Based Study
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DOI：
10.1111/pde.12237
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发表时间：
2014-01-01
影响因子：
1.5
通讯作者：
Tang, Jean Y.
中科院分区：
文献类型：
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作者：
Fu, Teresa;Keiser, Elizabeth;Tang, Jean Y.
在多民族人群水平上，食物和环境过敏原对湿疹风险的影响尚不清楚。我们的目的是确定根据较高的特异性免疫球蛋白E （IgE）水平测量的特定饮食和环境过敏原的致敏性是否与儿童湿疹风险相关。全国健康和营养调查调查的参与者年龄在1到17岁之间，他们被问及是否曾经从医生那里得到湿疹的诊断（n = 538）。测定4种膳食过敏原（鸡蛋、牛奶、花生和虾）和5种环境过敏原（尘螨、猫、狗、曲霉和Alternaria）的血清总IgE和特异性IgE水平。采用Logistic回归检验湿疹与IgE水平之间的关系。在美国，1040万儿童（15.6%）有湿疹史。湿疹在黑人儿童（p < 0.001）和高收入、高教育家庭的儿童中更为常见（p = 0.01）。有湿疹史的儿童总IgE水平中位数高于无湿疹史的儿童（66.4 vs 50.6 kU/L, p = 0.004）。在校正了年龄、种族、性别、家庭收入、家庭教育程度和医生诊断的哮喘的多因素分析中，湿疹与猫皮屑致敏性显著相关（优势比[OR] = 1.2, 95%可信区间[CI] 1.05, 1.4, p = 0.009）和狗皮屑致敏性显著相关（OR = 1.5, 95% CI, 1.2, 1.7, p < 0.001）。经过多次比较校正后，只有对狗皮屑的致敏性仍然显著。患有湿疹的美国儿童最有可能对狗皮屑过敏。未来的前瞻性研究应进一步探讨这种关系。
The relationship between food and environmental allergens in contributing to eczema risk is unclear on amultiethnic population level. Our purpose was to determine whether sensitization to specific dietary and environmental allergens as measured according to higher specific immunoglobulin E (IgE) levels is associated with eczema risk in children. National Health and Nutrition Examination Survey participants ages 1 to 17 years were asked whether they had ever received a diagnosis of eczema from a physician (n = 538). Total and specific serum IgE levels for four dietary allergens (egg, cow's milk, peanut, and shrimp) and five environmental allergens (dust mite, cat, dog, Aspergillus, and Alternaria) were measured. Logistic regression was used to examine the association between eczema and IgE levels. In the United States, 10.4 million children (15.6%) have a history of eczema. Eczema was more common in black children (p < 0.001) and in children from families with higher income and education (p = 0.01). The median total IgE levels were higher in children with a history of eczema than in those without (66.4 vs 50.6 kU/L, p = 0.004). In multivariate analysis adjusted for age, race, sex, family income, household education, and physician-diagnosed asthma, eczema was significantly associated with sensitization to cat dander (odds ratio [OR] = 1.2, 95% confidence interval [CI] 1.05, 1.4, p = 0.009) and dog dander (OR = 1.5, 95% CI, 1.2, 1.7, p < 0.001). After correction for multiple comparisons, only sensitization to dog dander remained significant. U. S. children with eczema are most likely to be sensitized to dog dander. Future prospective studies should further explore this relationship.