Crude caffeine reduces memory impairment and amyloid β1-42 levels in an Alzheimer's mouse model
Crude caffeine reduces memory impairment and amyloid β1-42 levels in an Alzheimer's mouse model
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DOI：
10.1016/j.foodchem.2012.04.148
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发表时间：
2012-12-01
期刊：
影响因子：
8.8
通讯作者：
Cheng, Irene H.
中科院分区：
文献类型：
--
作者：
Chu, Yi-Fang;Chang, Wen-Han;Cheng, Irene H.
阿尔茨海默病（AD）是一种慢性神经退行性疾病，与脑中淀粉样蛋白β（A β）肽和氧化应激的异常积累相关，是老年人中最常见的痴呆形式。粗品咖啡因（CC）是咖啡脱咖啡因的主要副产品，具有有效的亲水性抗氧化活性，可以减少炎症过程。在这里，我们表明CC和纯咖啡因摄入量在AD小鼠模型中具有有益作用。CC或纯咖啡因给药2个月可部分预防AD小鼠的记忆障碍，CC比纯咖啡因的效果更好。此外，消费CC，而不是纯咖啡因，降低了A β（1-42）水平和海马体中淀粉样斑块的数量。此外，CC和咖啡因保护原代神经元免受A β诱导的细胞死亡，并抑制A β诱导的caspase-3活性。我们的数据表明，CC可能含有预防剂对细胞死亡和记忆障碍的AD。(C)2012爱思唯尔有限公司版权所有。
Alzheimer's disease (AD), a chronic neurodegenerative disorder associated with the abnormal accumulations of amyloid beta(A beta) peptide and oxidative stress in the brain, is the most common form of dementia among the elderly. Crude caffeine (CC), a major by-product of the decaffeination of coffee, has potent hydrophilic antioxidant activity and may reduce inflammatory processes. Here, we showed that CC and pure caffeine intake had beneficial effects in a mouse model of AD. Administration of CC or pure caffeine for 2 months partially prevented memory impairment in AD mice, with CC having greater effects than pure caffeine. Furthermore, consumption of CC, but not pure caffeine, reduced the A beta(1-42) levels and the number of amyloid plaques in the hippocampus. Moreover, CC and caffeine protected primary neurons from A beta-induced cell death and suppressed A beta-induced caspase-3 activity. Our data indicate that CC may contain prophylactic agents against the cell death and the memory impairment in AD. (C) 2012 Elsevier Ltd. All rights reserved.