DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder.
DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder.
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DLGAP1 和 NMDA 受体相关突触后密度蛋白基因影响注意缺陷多动障碍的执行功能
DOI：
10.1002/brb3.914
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发表时间：
2018-03
影响因子：
3.1
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Fan Z;Qian Y;Lu Q;Wang Y;Chang S;Yang L
探讨DLGAP1基因与注意缺陷多动障碍（ADHD）儿童执行功能（EF）的关系。共有 763 名 ADHD 儿童和 140 名健康对照者入组。使用协方差分析 (ANCOVA) 分析 ADHD 和对照组之间 EF 的差异，其中智商、性别和年龄作为协变量。 SNP 与 EF 和 ADHD 三种症状特征的关联都是使用 PLINK 的加性线性回归模型进行的，其协变量与 ANCOVA 相同。与对照组相比，多动症儿童的认知灵活性和抑制能力较差。两个 SNP（rs2049161，p 值= 5.08e-7，调整后的 p 值= 1.63e-4，rs16946051，p 值= 5.18e-7，调整后的 p 值= 1.66e-4）在 Trail Making Test 中经受住了多次测试。两个 SNP 也显示与 TOH 相关（rs2049161，p = 6.82e-4，rs16946051，p = 7.91e-4）。对基因 DLGAP1 及其功能通路 DLGAP1-DLG4-NMDA 的基于集合的分析表明，它们与基因 (p = .0057) 和通路水平 (p = .0321) 的认知灵活性相关。此外，该基因和通路还显示与 ADHD 症状评分相关。相关的 SNP 及其 LD 代理与髓质和额叶皮质中 DLGAP1 的表达相关。患有 ADHD 的儿童表现出 EF 缺陷，尤其是认知灵活性和抑制能力。 DLGAP1与认知灵活性和计划相关，DLGAP1的作用可能是通过DLGAP1-DLG4-NMDA复合体来实现的。
To explore the association of DLGAP1 gene with executive function (EF) in attention deficit hyperactivity disorder (ADHD) children. A total of 763 ADHD children and 140 healthy controls were enrolled. The difference of EF between ADHD and controls was analyzed using the analysis of covariance (ANCOVA), with IQ, sex, and age as covariates. Both the associations of SNPs with EF and three symptom traits of ADHD were conducted using an additive linear regression model by PLINK with the same covariates as ANCOVA. Compared with controls, children with ADHD showed poorer cognitive flexibility and inhibition. Two SNPs (rs2049161, p‐value = 5.08e‐7, adjusted p‐value = 1.63e‐4, rs16946051, p‐value = 5.18e‐7, adjusted p‐value = 1.66e‐4) survived multiple tests in Trail Making Test. Both SNPs also showed association with TOH (rs2049161, p = 6.82e‐4, rs16946051, p = 7.91e‐4). Set‐based analysis for gene DLGAP1 and its functional pathway DLGAP1‐DLG4‐NMDA showed they were associated with cognitive flexibility at both gene (p = .0057) and pathway level (p = .0321). Furthermore, the gene and pathway also showed association with ADHD symptom score. The associated SNPs and their LD proxies were related to the expression of DLGAP1 in medulla and frontal cortex. Children with ADHD showed deficit in EF, especially, cognitive flexibility and inhibition. DLGAP1 was associated with cognitive flexibility and plan, and the role of DLGAP1 might be implemented through the complex of DLGAP1‐DLG4‐NMDA.
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影响因子：
3.3
作者：
Desteno, D. A.;Schmauss, C.
通讯作者：
Schmauss, C.
来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
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影响因子：
3.1
作者：
Chang, Jane Pei-Chen;Lane, Hsien-Yuan;Tsai, Guochuan E.
通讯作者：
Tsai, Guochuan E.
DOI：
10.1016/j.psc.2009.12.004
发表时间：
2010-03
期刊：
The Psychiatric clinics of North America
影响因子：
--
作者：
Faraone SV;Mick E
通讯作者：
Mick E
DOI：
10.1126/science.1262110
发表时间：
2015-05-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
GTEx Consortium
通讯作者：
GTEx Consortium