The effects of luteinizing hormone releasing hormone (LH-RH) in pregnant rats. I. Postnidatory effects.
The effects of luteinizing hormone releasing hormone (LH-RH) in pregnant rats. I. Postnidatory effects.
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黄体生成素释放激素（LH-RH）对怀孕大鼠的影响。
DOI：
10.1095/biolreprod16.5.614
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发表时间：
1977
影响因子：
3.6
通讯作者：
R. A. Edgren
中科院分区：
文献类型：
--
作者：
R. R. Humphrey;B. Windsor;J. Reel;R. A. Edgren
本文观察了LH-RH对大鼠妊娠的影响。在妊娠第9、10或11天单次注射500 mcg LH-RH可终止妊娠，而在第6-8或13-16天注射则几乎没有影响。b.i.d.第10天的艾德ED 50单次注射给药为150 mcg和550 mcg。第9天给药后，第10天和第11天循环孕酮水平降低。在第7-12天，给予大剂量孕酮逆转了LH-RH给药的作用。用雌二醇-17 β治疗没有增强孕酮的作用，但单独给药时似乎略微延迟胎儿吸收。结果表明，LH-RH的抗生育作用是通过功能性黄体溶解介导的。
The effects of LH-RH on pregnancy in rats were investigated. A single 500 mcg injection of LH-RH on Days 9, 10, or 11 of pregnancy terminated pregnancy, whereas injection on Days 6-8 or 13-16 had little or no effect. The ED 50 on Day 10 for b.i.d. administration was 150 mcg and 550 mcg for a single injection. Administration on Day 9 was followed by a decrease in circulating progesterone levels on Days 10 and 11. The administration of large doses of progesterone reversed the effects of LH-RH administration on Days 7-12. Treatment with estradiol-17beta did not potentiate the effect of progesterone, but appeared to slightly retard fetal resorption when administered alone. The results suggest that the antifertility effect of LH-RH is mediated via functional luteolysis.