Thrombospondin-2 as a Potential Risk Factor in a General Population
Thrombospondin-2 as a Potential Risk Factor in a General Population
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DOI：
10.1536/ihj.18-246
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发表时间：
2019-03-01
影响因子：
1.5
通讯作者：
Fukumoto, Yoshihiro
中科院分区：
文献类型：
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作者：
Morikawa, Nagisa;Adachi, Hisashi;Fukumoto, Yoshihiro
血清血栓反应蛋白-2(TSP-2)是一种在细胞外基质(ECM)中表达的糖蛋白，在组织重塑过程中增加。最近的研究表明，TSP-2是心力衰竭(HF)患者心血管死亡的有用预测指标。然而，Scrum TSP-2水平在普通人群中的临床重要性仍不清楚。因此，我们旨在阐明TSP-2与临床危险因素之间的关系。对日本长崎市宇久镇的一个社区居民进行了定期流行病学调查。共有445名居民接受了健康检查，包括血液检查，如空腹血清TSP-2水平。对TSP-2与临床危险因素的关系进行单因素和多因素分析。所有统计分析用SAS v9.4程序进行。年龄的平均t标准差为67.0±9.4岁。尽管血清TSP-2水平(平均值：20.9+/-8.5 ng/m L)无性别差异，但它们与血糖(P<；0.001)、胰岛素(P<；0.01)、稳态模型胰岛素抵抗评估(P<；0.001)、估计肾小球滤过率(P<；0.01)显著相关。高敏C反应蛋白(P<；0.001)、房颤史(P<；0.001)、心血管疾病史(P<；0.001)和脑钠素N末端前体(NT-proBNP)(P<；0.001)。多元线性回归分析显示，TSP-2水平与房颤史(P<；0.0001)、HOMA-IR(P<；0.001)、超敏C反应蛋白(P=0.011)、NT-ProBNP(P=0.043)独立相关。这些结果表明在普通人群中TSP-2与临床危险因素之间存在显著的相关性。这表明它是心脏病发病率和死亡率的预测因子。
Serum thrombospondin-2 (TSP-2) is a glycoprotein expressed in the extracellular matrix (ECM), which increases during tissue remodeling. It has been shown in recent studies that TSP-2 is a useful predictor of cardiovascular death in patients with heart failure (HF). However, the clinical importance of scrum TSP-2 levels in a general population is still unknown. Therefore, we aimed to clarify the association between TSP-2 and clinical risk factors. A periodic epidemiological survey was performed in a community dwelling in the town of Uku, Nagasaki, Japan. A total of 445 residents received a health checkup examination including blood tests such as fasting serum levels of TSP-2. Uni- and multivariate analyses were performed to examine the relationship between TSP-2 and clinical risk factors. All statistical analyses were performed using SAS v9.4 program. The mean t standard deviation of age was 67.0 +/- 9.4 years old. Although serum TSP-2 levels (mean: 20.9 +/- 8.5 ng/mL) showed no significant sex difference, they were significantly correlated with the levels of plasma glucose (P < 0.001), insulin (P < 0.01), homeostasis model assessment of insulin resistance (HOMA-IR) (P < 0.001), estimated glomerular filtration rate (eGFR) (P < 0.01. inversely), high-sensitivity C-reactive protein (hs-CRP) (P < 0.001), history of atrial fibrillation (P < 0.001), history of cardiovascular diseases (P < 0.001), and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) (P < 0.001). Moreover, in the multiple stepwise linear regression analysis, the levels of TSP-2 were independently and significantly associated with the history of atrial fibrillation (P < 0.0001), HOMA-IR (P < 0.001), high-sensitivity CRP (P = 0.011), and NT-proBNP (P = 0.043). These results indicated the significant relationship between TSP-2 and clinical risk factors in a general population. suggesting its role as a predictor of heart disease morbidity and mortality.