A technical report on exhaled nitric oxide measurement: asthma monitoring in athletes.
A technical report on exhaled nitric oxide measurement: asthma monitoring in athletes.
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关于呼出一氧化氮测量的技术报告：运动员哮喘监测。
DOI：
10.1088/1752-7155/2/3/037027
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发表时间：
2008
影响因子：
3.8
通讯作者：
Dweik,RaedA
中科院分区：
文献类型：
--
作者：
Grob,NataliaM;Laskowski,Daniel;Dweik,RaedA
呼出NO（FE NO）测量已被用作诊断哮喘的标记物以及用于监测气道炎症和对抗炎药物的反应的非侵入性工具。这种非侵入性监测的一个领域可能是有帮助的哮喘运动员，因为他们训练的竞争性事件。我们假设，在训练过程中，哮喘患者可能会经历肺部炎症的恶化，反映在FE NO水平上，这可能太微妙而无法通过常规方法（如肺量测定法）检测到。数据收集从哮喘患者（n= 1）的耐力训练过程中使用的桌面（NIOX）和便携式NO（MINO）分析仪，每天八周。我们发现，在台式系统中测量的平均NO水平与两种便携式分析仪相关性良好（r 2= 0.73，r 2= 0.74; p< 0.0001）;此外，两种MINO设备之间存在强相关性（r 2= 0.88; p< 0.0001）。一个强大的负相关关系之间存在的英里数运行和NO，无论使用的设备。然而，FEV 1和PEF并没有随着跑英里数的增加而显著改变.哮喘患者的运动训练与NO水平的降低（改善）有关，但FEV 1和PEF无显著变化。这表明呼出的NO水平可能比传统的肺功能测试对运动引起的气道变化更敏感。
Exhaled NO (FE NO) measurements have been utilized as a marker to diagnose asthma as well as a non-invasive tool for monitoring airway inflammation and the response to anti-inflammatory medications. One area where this non-invasive monitoring may be helpful is for asthmatic athletes as they train for competitive events. We hypothesized that in the course of training an asthmatic individual may experience worsening of lung inflammation reflected in FE NO levels that may be too subtle to detect by conventional methods like spirometry. Data were collected from an asthmatic patient (n= 1) over the course of endurance training using both the desktop (NIOX) and the portable NO (MINO) analyzers daily for eight weeks. We found that average NO levels measured in the desktop system correlated well with the two portable analyzers (r 2= 0.73, r 2= 0.74; p< 0.0001); additionally, there was a strong correlation between the two MINO devices (r 2= 0.88; p< 0.0001). A strong negative relationship existed between the number of miles run and NO, regardless of the device used. FEV 1 and PEF, however, did not change significantly as the miles run increased. Exercise training in asthmatics was associated with a decrease (improvement) in NO levels but no significant change in FEV 1 and PEF. This suggests that exhaled NO levels may be more sensitive to changes in the airway as a result of exercise than traditional pulmonary function testing.