Biodegradable Ethylene-Bis(Propyl)Disulfide-Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In-Vitro Drug Delivery
Biodegradable Ethylene-Bis(Propyl)Disulfide-Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In-Vitro Drug Delivery
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DOI：
10.1002/adma.201401931
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发表时间：
2014-09-17
影响因子：
29.4
通讯作者：
Durand, Jean-Olivier
中科院分区：
文献类型：
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作者：
Croissant, Jonas;Cattoen, Xavier;Durand, Jean-Olivier
以1，4-二(三乙氧基硅基)乙烯和二(3-乙氧基硅丙基)二硫化物为原料合成了周期性介孔有机硅纳米棒和纳米球。纳米系统呈现出六方纳米结构的长程有序。它们在模拟的生理条件下被降解。阿霉素在这些纳米系统中的载药和释药均依赖于pH。这些纳米颗粒被乳腺癌细胞内吞，在这些细胞中对阿霉素的输送非常有效。
Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4-bis(triethoxysilyl)ethylene and bis(3-ethoxysilylpropyl)disulfide. The nanosystems present the long-range order of the hexagonal nanostructure. They are degraded in simulated physiological conditions. The loading and release of doxorubicin with these nanosystems are both pH dependent. These nanoparticles are endocytosed by breast cancer cells and are very efficient for doxorubicin delivery in these cells.