Neuromodulation of cognition in Parkinson's disease.
Neuromodulation of cognition in Parkinson's disease.
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DOI：
10.1016/bs.pbr.2022.01.016
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发表时间：
2022
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神经调节是一种广泛应用于帕金森病（PD）运动症状的治疗方法。由于对PD中与运动症状相关的电路功能障碍的了解，它可能是一种非常有效的治疗方法。然而，帕金森病认知症状的机制尚不清楚，神经调节对这些症状的影响也不太一致。尽管如此，神经调节提供了一个独特的机会来调节运动和认知回路，同时尽量减少偏离目标的副作用。我们回顾了PD中使用的神经调节方式及其对认知症状的潜在影响。有创性和无创性神经调节方式都有一些令人鼓舞的发现，并且在治疗性神经调节领域取得了有希望的进展。需要大量的工作来确定哪种调节靶点对不同类型的PD认知缺陷最有效。
Neuromodulation is a widely used treatment for motor symptoms of Parkinson’s disease (PD). It can be a highly effective treatment as a result of knowledge of circuit dysfunction associated with motor symptoms in PD. However, the mechanisms underlying cognitive symptoms of PD are less well-known, and the effects of neuromodulation on these symptoms are less consistent. Nonetheless, neuromodulation provides a unique opportunity to modulate motor and cognitive circuits while minimizing off-target side effects. We review the modalities of neuromodulation used in PD and the potential implications for cognitive symptoms. There have been some encouraging findings with both invasive and noninvasive modalities of neuromodulation, and there are promising advances being made in the field of therapeutic neuromodulation. Substantial work is needed to determine which modulation targets are most effective for the different types of cognitive deficits of PD.