Semisynthetic Derivatives of Sesquiterpene Lactones by Palladium-Catalyzed Arylation of the α-Methylene-γ-lactone Substructure
Semisynthetic Derivatives of Sesquiterpene Lactones by Palladium-Catalyzed Arylation of the α-Methylene-γ-lactone Substructure
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DOI：
10.1021/jo901533e
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发表时间：
2009-09-18
影响因子：
3.6
通讯作者：
Colby, David A.
中科院分区：
文献类型：
--
作者：
Han, Changho;Barrios, Francis J.;Colby, David A.
钯催化的不同含α-亚甲基-γ-内酯的倍半萜内酯的芳基化被证明可以以中等至优异的产率选择性地生产E-烯烃偶联产物。对 HeLa 细胞中这些半合成倍半萜内酯衍生物的生物学评估显示出有趣的抗增殖特性，并提供了初步的结构活性数据。
The palladiurn-catalyzed arylation of different alpha-methylene-gamma-lactone-containing sesquiterpene lactones was shown to produce E-olefin coupling products selectively in moderate to excellent yields. Biological evaluation of these semisynthetic sesquiterpene lactone derivatives in HeLa cells showed interesting antiproliferative profiles and provided initial structure-activity data.