Full-field electroretinogram findings in children in the atropine treatment for myopia (ATOM2) study
Full-field electroretinogram findings in children in the atropine treatment for myopia (ATOM2) study
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DOI：
10.1007/s10633-012-9372-8
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发表时间：
2013-06-01
影响因子：
1.4
通讯作者：
Luu, Chi D.
中科院分区：
文献类型：
--
作者：
Chia, Audrey;Li, Wen;Luu, Chi D.
本研究的目的是确定近视对儿童全视野视网膜电图（ffERG）的纵向影响，以及阿托品治疗是否有任何影响。随机选择50名儿童参加阿托品治疗近视研究，其中35名儿童同意在基线时接受ffERG检查（阿托品治疗前）、24个月（治疗结束时）和32个月（停止治疗后8个月）。扩展的ISCEV ffERG方案用于所有记录。分析了眼轴长度（AL）与暗视和明视ffERG反应的关系：a波和b波振幅和隐式时间、饱和振幅（V（max））和视网膜敏感度（logK）（平均年龄：9.5 +/- A 0.8岁，平均等效球镜：-5.0 +/- A 1.6 D）。基线时，AL和logK之间检测到的相关性为0.37（p = 0.047）。AL和V（max）或任何暗视和明视ffERG振幅和内隐时间测量之间无显著相关性。纵向数据表明，随着时间的推移，明视a波和b波以及30 Hz闪烁反应幅度减少。多因素分析表明，30 Hz闪烁响应幅度的变化可能与AL的变化有关。没有证据表明其他反应的变化与年龄、基线AL或阿托品剂量有关。近视儿童的视网膜敏感性降低。随着时间的推移，视锥细胞功能逐渐下降，这不受阿托品治疗的影响。
The aims of this study were to determine the longitudinal effects of myopia on full-field electroretinogram (ffERG) in children, and whether there were any effects due to atropine treatment.Fifty children, enrolled in the atropine treatment for myopia study, were randomly selected and 35 children consented to undergo ffERG at baseline (prior to atropine treatment), 24 months (at end of treatment) and 32 months (8 months after cessation of treatment). An extended ISCEV ffERG protocol was used for all recordings. The relationship between axial length (AL) and the following scotopic and photopic ffERG responses was analyzed: a- and b-wave amplitude and implicit time, saturated amplitude (V (max)), and retinal sensitivity (logK).Reliable ffERG recordings with acceptable level of noise were obtained on all 3 visits from 29 children (mean age: 9.5 +/- A 0.8 years and mean spherical equivalent: -5.0 +/- A 1.6 D). At baseline, the correlation detected between AL and logK was 0.37 (p = 0.047). There was no significant correlation between AL and V (max) or any scotopic and photopic ffERG amplitude and implicit time measures. Longitudinal data suggested a reduction in photopic a- and b-wave and 30 Hz flicker response amplitudes over time. Multivariate analysis showed that the change in 30 Hz flicker response amplitude was likely to be associated with AL change. There was no evidence that changes in other responses were associated with age, baseline AL, or atropine dose used.Retinal sensitivity was reduced in myopic children. There was a gradual decline in cone function over time which was not influenced by atropine treatment.