Innocuous-related sural nerve-evoked and finger-evoked potentials generated in the primary somatosensory and supplementary motor cortices.
Innocuous-related sural nerve-evoked and finger-evoked potentials generated in the primary somatosensory and supplementary motor cortices.
复制标题
在初级体感和辅助运动皮质中产生无害相关的腓肠神经诱发电位和手指诱发电位。
DOI：
10.1016/s1388-2457(99)00203-5
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Schell,S
中科院分区：
文献类型：
--
作者：
Dowman,R;Schell,S
我们早期的工作揭示了躯体感觉诱发电位的两个成分，我们将其标记为SP1和SP4a，它们似乎是由参与躯体感觉无害方面的神经元产生的。本研究的目的是验证我们早期工作中提出的一个假设，即SP1和SP4a是在初级躯体感觉皮层产生的。方法对20名受试者进行手指和腓肠神经电刺激诱发的SP1和SP4a的偶极子源定位方法。结果手指诱发的SP1和腓肠神经诱发的SP1分别与初级躯体感觉皮层(SI)、手部和足部的单一来源匹配最好。手指诱发的SP4a和腓肠神经诱发的SP4a最适合位于辅助运动区的单一来源。结论上述结果与我们的假设一致，即SP1反映了参与无害性躯体感觉的SI神经元的活动。SP4a不是像我们最初假设的那样在SI中生成，而是在SMA中生成。SP4a幅值-刺激强度函数和SP4a源位置对诱发刺激点的依赖而不是对记录幅度等级的手的依赖表明，SP4a反映了SMA神经元对来自无害体感通路的传入输入的反应。因此，SP4a可能是由SMA活动产生的，SMA参与了感觉引导的选择和/或运动反应的产生。
ObjectiveOur earlier work revealed two components of the somatosensory evoked potential, which we have labeled SP1 and SP4a, that appear to be generated by neurons involved in the innocuous aspects of somatosensation. The objective of the present study was to examine a hypothesis developed in our earlier work, namely that SP1 and SP4a are generated in the primary somatosensory cortex.MethodsThe dipole source localization method was applied to SP1 and SP4a evoked by electrical stimulation of the fingers and of the sural nerve in 20 subjects. The subjects rated the subjective magnitude of each stimulus on a 9 point scale.ResultsThe finger-evoked and sural nerve-evoked SP1 were best-fit by single sources located in the primary somatosensory cortex (SI) hand and foot areas, respectively. Both the finger-evoked and the sural nerve-evoked SP4a, on the other hand, were best-fit by a single source located in the supplementary motor area (SMA).ConclusionsThese results are consistent with our hypothesis that SP1 reflects the activity of SI neurons that are involved in innocuous somatosensation. SP4a is not generated in SI as we originally hypothesized, but rather in the SMA. The SP4a amplitude-stimulus intensity function and the dependence of the SP4a source location on the evoking stimulus site and not the hand registering the magnitude rating suggests that SP4a reflects the response of SMA neurons to afferent input from the innocuous somatosensory pathways. Hence, SP4a may be generated by SMA activity involved in the sensory-guided selection and/or generation of motor responses.