Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study
Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study
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DOI：
10.1093/humrep/deh238
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发表时间：
2004-06-01
影响因子：
6.1
通讯作者：
Nappi, C
中科院分区：
文献类型：
--
作者：
Guida, M;Acunzo, G;Nappi, C
背景：进行了一项前瞻性、随机、对照研究，以评估自交联透明质酸（ACP）凝胶预防宫腔镜手术后发生新生宫内粘连的疗效。方法：132例单一手术可修复的宫内病变（肌瘤、息肉和子宫间隔，亚组I-III）患者完成了研究。将患者随机分为两组：A组行宫腔镜手术加宫内应用ACP凝胶（10 ml）， B组单独行宫腔镜手术（对照组）。术后3个月计算各组及亚组的粘连形成率及粘连评分。结果：与对照组相比，A组在随访3个月时出现新生宫内粘连的情况明显减少。此外，在使用ACP凝胶治疗的患者中，粘连的分期显示粘连严重程度显著降低。结论：ACP凝胶可显著降低宫腔镜术后子宫内粘连从头形成的发生率和严重程度。
BACKGROUND: A prospective, randomized, controlled study was performed to assess the efficacy of auto-crosslinked hyaluronic acid (ACP) gel to prevent the development of de-novo intrauterine adhesions following hysteroscopic surgery. METHODS: One hundred and thirty-two patients with a single surgically remediable intrauterine lesion (myomas, polyps and uterine septa, subgroups I-III) completed the study. Patients were randomized to two different groups: group A underwent hysteroscopic surgery plus intrauterine application of ACP gel (10 ml) while group B underwent hysteroscopic surgery alone (control group). The rate of adhesion formation and the adhesion score was calculated for each group and subgroup 3 months after surgery. RESULTS: Group A showed a significant reduction in the development of de-novo intrauterine adhesions at 3 months follow-up in comparison with the control group. Furthermore, the staging of adhesions showed a significant decrease in adhesion severity in patients treated with ACP gel. CONCLUSIONS: ACP gel significantly reduces the incidence and severity of de-novo formation of intrauterine adhesions after hysteroscopic surgery.