Iron and ADHD: Time to Move Beyond Serum Ferritin Levels
Iron and ADHD: Time to Move Beyond Serum Ferritin Levels
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DOI：
10.1177/1087054711430712
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发表时间：
2013-05-01
影响因子：
3
通讯作者：
Cortese, Samuele
中科院分区：
文献类型：
--
作者：
Donfrancesco, Renato;Parisi, Pasquale;Cortese, Samuele
目的：(a) 比较未接受兴奋剂的 ADHD 儿童样本和匹配对照组的血清铁蛋白水平，(b) 评估血清铁蛋白与 ADHD 症状严重程度、ADHD 亚型和智商的关联。方法：ADHD 组和对照组分别包括 101 名和 93 名儿童。采用酶联免疫吸附测定法测定血清铁蛋白水平。结果：ADHD 儿童与对照组以及 ADHD 亚型之间的血清铁蛋白没有显着差异。血清铁蛋白水平与 IQ 或 ADHD 严重程度相关的测量值之间的相关性不显着。结论：这是评估未接触过兴奋剂的 ADHD 儿童铁蛋白水平的最大对照研究。这项研究的结果并不支持血清铁蛋白水平与 ADHD 之间存在显着关系。然而，基于神经生物学假设和初步经验证据，作者基于外周铁测量的结果并不能排除多动症中大脑缺铁的可能影响。
Objective: (a) To compare serum ferritin levels in a sample of stimulant-naive children with ADHD and matched controls and (b) to assess the association of serum ferritin to ADHD symptoms severity, ADHD subtypes, and IQ. Method: The ADHD and the control groups included 101 and 93 children, respectively. Serum ferritin levels were determined with the enzyme-linked immunosorbent assay method. Results: Serum ferritin did not significantly differ between children with ADHD and controls, as well as among ADHD subtypes. Correlations between serum ferritin levels and measures related to IQ or ADHD severity were not significant. Conclusion: This is the largest controlled study that assessed ferritin levels in stimulant-naive ADHD children. The findings of this study do not support a significant relationship between serum ferritin levels and ADHD. However, the authors' results based on peripheral measures of iron do not rule out a possible implication of brain iron deficiency in ADHD, grounded on neurobiological hypotheses and preliminary empirical evidence.