Erythrocytes are essential for development of cerebral vasculopathy resulting from subarachnoid hemorrhage in cats.
Erythrocytes are essential for development of cerebral vasculopathy resulting from subarachnoid hemorrhage in cats.
复制标题
红细胞对于猫蛛网膜下腔出血引起的脑血管病的发展至关重要。
作者：
Duff,TA;Louie,J;Feilbach,JA;Scott,G
为了确定哪些血液元素在脑血管痉挛的发展中起关键作用，成年猫接受自体全血或含乳胶珠的无红细胞血液作为替代形态学标记物的脑桥前注射。7天或10天后，麻醉猫并用固定剂灌注，制备基底动脉用于光镜和电镜。通过血管外膜内存在大量红细胞或乳胶珠证实凝块沉积成功。与以前的研究一致，滴注全血产生管腔狭窄，与血管壁各层的深刻超微结构变化相关。然而，在无红细胞血液中浸泡的动脉中没有发生显著变化。这些研究结果表明，首先，红细胞是必不可少的慢性脑血管痉挛相关的血管病变的发展，第二，其他血液元素的作用，如果有的话，是不是自主的。
In an effort to determine which blood elements play a critical role in the development of cerebral vasospasm, adult cats were subjected to prepontine injection of either autogenous whole blood or erythrocyte-free blood containing latex beads as a substitute morphologic marker. Seven or 10 days later the cats were anesthetized and perfused with fixative, and the basilar arteries were prepared for light and electron microscopy. Successful clot deposition was confirmed by the presence of numerous erythrocytes or latex beads within the adventitia of vessels. In agreement with previous studies, instillation of whole blood produced luminal narrowing associated with profound ultrastructural changes in all layers of the vascular wall. No significant alterations, however, occurred in arteries bathed in erythrocyte-free blood. These findings suggest first, that erythrocytes are essential for the development of the vasculopathy associated with chronic cerebral vasospasm, and second, that the role, if any, of other blood elements is not autonomous.