The vascular endothelium in normal pregnancy and pre-eclampsia.
The vascular endothelium in normal pregnancy and pre-eclampsia.
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正常妊娠和先兆子痫中的血管内皮。
DOI：
10.1530/ror.0.0010107
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Ian A. Greer
中科院分区：
文献类型：
--
作者：
Fiona Lyall;Ian A. Greer
妊娠期高血压疾病影响到15%的妊娠，最严重的形式，先兆子痫，是当今英国孕产妇死亡的主要原因。子痫前期是一种影响人体几乎所有器官和系统的多系统疾病，高血压和蛋白尿是传统的诊断特征，代表了复杂病理生理过程的两个方面。无论在胎盘床、肾微血管、肝脏、心脏还是脑循环的个别血管中，该疾病的共同病理特征都是血管内皮损伤和功能障碍。在发现预防或改善妊娠期高血压疾病的新方法之前，我们必须首先了解临床问题背后的病理生理机制。这篇综述总结了内皮功能障碍在妊娠高血压疾病中起关键作用的证据，并将重点关注最严重的形式，先兆子痫。
Hypertensive disorders of pregnancy affect up to 15% of pregnancies and the most severe form, pre-eclampsia, is the leading cause of maternal death in the UK today. Pre-eclampsia is a multisystem disorder affecting virtually every organ and system in the body, with hypertension and proteinuria, the traditional diagnostic features, representing two facets of a complex pathophysiological process. The common pathological feature of the disease, whether in the decidual vessels of the placental bed, renal microvasculature, liver, heart or cerebral circulation, is vascular endothelial damage and dysfunction. Before new ways of preventing or ameliorating hypertensive disorders of pregnancy can be found, we must first understand the pathophysiological mechanisms underlying the clinical problem. This review summarizes the evidence that endothelial dysfunction plays a key role in hypertensive disorders of pregnancy and will focus on the most severe form, pre-eclampsia.