Silver-mediated radical cyclization of alkynoates and α-keto acids leading to coumarins via cascade double C-C bond formation.
Silver-mediated radical cyclization of alkynoates and α-keto acids leading to coumarins via cascade double C-C bond formation.
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DOI：
10.1021/jo502474z
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发表时间：
2015-01
期刊：
影响因子：
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通讯作者：
Kelu Yan;Daoshan Yang;Wei Wei-Wei;Fen Wang;Yu Shuai;Qiannan Li;Hua Wang
中科院分区：
文献类型：
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作者：
Kelu Yan;Daoshan Yang;Wei Wei-Wei;Fen Wang;Yu Shuai;Qiannan Li;Hua Wang
本文报道了一种简便、新颖的银催化自由基环化反应方法，该方法通过α-酮酸与炔酸酯的直接双官能化反应，在温和条件下形成双C-C键，合成香豆素衍生物。该方法具有原料易得、效率高、实用性强等优点。本方法为香豆素基序的构建提供了一种有效的策略。
A novel and convenient silver-mediated radical cyclization method for the synthesis of coumarin derivatives via the direct difunctionalization of alkynoates with α-keto acids through double C-C bond formation under mild conditions has been developed. This new method is highly efficient and practical, and the starting materials are readily prepared. The present method should provide a useful strategy for the construction of coumarin motifs.