Controversies in communication of genetic screening results for cancer: a report from the American Society of Preventive Oncology's Screening Special Interest Group (ASPO's 33rd Annual Meeting, March 8 to 10, 2009, Tampa, Florida).
Controversies in communication of genetic screening results for cancer: a report from the American Society of Preventive Oncology's Screening Special Interest Group (ASPO's 33rd Annual Meeting, March 8 to 10, 2009, Tampa, Florida).
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DOI：
10.1158/1055-9965.epi-19-2-aspo01
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Terry MB
中科院分区：
文献类型：
--
作者：
Patrick-Miller L;Bradbury AR;Terry MB
Genetic screening for cancer susceptibility for many cancer sites has become routine for high-risk populations, particularly breast, ovarian, and colon cancer. Such genetic tests hold great promise for informing tailored cancer prevention and risk reduction recommendations. Heightened consumer awareness of “cancer genes” and tests to detect them has escalated interest and demand for cancer risk assessment, generating a pressing need to identify effective, efficient methods of communicating complicated genetic information to patients and their potentially at-risk relatives. As more is learned about cancer genetic susceptibility, population-level demand for genetic screening will necessitate considering new modes and methods for effective genetic risk communication other than traditional in-person genetic counseling. Optimal outcomes of predictive genetic testing for cancer include adherence to preventive or risk-reducing strategies, accurate communication of test results to at-risk relatives, maximization of psychosocial well-being, and ultimately, reduction of morbidity and mortality associated with hereditary or familial cancers. This will require the effective communication of risk information tailored to patients' translation of knowledge into perceptions of cancer risk, and the biopsychosocial factors that mediate and moderate that translation into risk-reduction behaviors. Two very important issues in the effective communication of genetic screening results include (a) the mode of communication and (b) the age of subjects who receive risk information. Thus, the purpose of this session was to review the state of knowledge and to identify the future research necessary to inform policy and practice about testing for, and communication of, cancer risk information to adults and minors. The example used in this session was BRCA1/2 testing, given its widespread use at the population-level in adults.
