Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene.
Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene.
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曲古抑菌素 A 激活 p18INK4c 基因：差异激活及与 p19INK4d 基因的配合。
DOI：
10.1016/j.febslet.2004.08.025
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Sakai,Toshiyuki
中科院分区：
文献类型：
--
作者：
Yokota,Tomoya;Matsuzaki,Youichirou;Sakai,Toshiyuki
We have reported that histone deacetylase (HDAC) inhibitors activate a member of the INK4 family, the p19INK4dgene, causing G1 phase arrest. We report here that HDAC inhibitor, Trichostatin A, activates another member of the INK4 family, the p18INK4cgene, through its promoter in Jurkat cells. Interestingly, the activation patterns of the p18INK4cgene were different from those of p19INK4d. Furthermore, mouse embryo fibroblasts lacking p18Ink4cor p18Ink4c/p19Ink4dwere resistant to the growth inhibitory effects of TSA as compared to their wild-type counterpart. Our findings suggest that p18INK4cis involved in TSA-mediated cell growth inhibition and cooperates with p19INK4d.
