Antigenicity and immunogenicity of synthetic peptides
Antigenicity and immunogenicity of synthetic peptides
复制标题
DOI：
10.1006/biol.2001.0308
复制
发表时间：
2001-09-01
期刊：
影响因子：
1.7
通讯作者：
Van Regenmortel, MHV
中科院分区：
文献类型：
--
作者：
Van Regenmortel, MHV
肽与互补抗体的功能结合位点特异性反应的能力被称为其抗原反应性或抗原性。近年来，主要通过肽-单克隆抗体复合物的X射线晶体学分析，我们对肽抗原性的理解有了相当大的提高。这些知识是沿着还原论的路线获得的，方法是将抗原识别的生物学问题转化为用原子力和非共价键描述的蛋白质-肽相互作用的纯化学现象。这使得有可能提高肽和单克隆抗体之间的空间互补性程度，从而按照基于结构的合理设计原则提高肽的抗原性。免疫原性是肽在感受态宿主中诱导免疫应答的能力，其情况完全不同。尽管抗原性可以降低到化学水平，但在免疫原性的情况下，这种降低是无法实现的，免疫原性取决于与宿主免疫系统的各种元件的许多复杂相互作用。这些细胞和调节机制不能通过以预定方式调节肽的结构来控制。由于这个原因，不可能使用分子设计原理开发合成肽疫苗。(C)2001年，国际生物制品协会。
The ability of a peptide to react specifically with the functional binding site of a complementary antibody is known as its antigenic reactivity or antigenicity. Our understanding of peptide antigenicity has improved considerably in recent years mainly through the X-ray crystallographic analysis of peptide-monoclonal antibody complexes. This knowledge is obtained along reductionist lines by turning the biological question of antigen recognition into the purely chemical phenomenon of protein-peptide interactions described in terms of atomic forces and non-covalent bonds. This makes it possible to improve the degree of steric complementarity between a peptide and a single monoclonal antibody and thus to improve the peptide's antigenicity following structure-based rational design principles.The situation is quite different with immunogenicity which is the ability of the peptide to induce an immune response in a competent host. Whereas antigenicity can be reduced to the level of chemistry, such a reduction is not achievable in the case of immunogenicity which depends on many complex interactions with various elements of the host immune system. These cellular and regulatory mechanisms cannot be controlled by adjusting the structure of the peptide in a predetermined manner. For this reason, it is not possible to develop a synthetic peptide vaccine using molecular design principles. (C) 2001 The International Association for Biologicals.