Studies on antinephritic effect of TJ-8014, a new Japanese herbal medicine (3): Effects on crescentic-type anti-GBM nephritis in rats.
Studies on antinephritic effect of TJ-8014, a new Japanese herbal medicine (3): Effects on crescentic-type anti-GBM nephritis in rats.
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日本新草药TJ-8014的抗肾病作用研究(3)：对大鼠新月体型抗GBM肾炎的作用。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
Y. Suzuki
中科院分区：
文献类型：
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作者：
T. Hattori;M. Itô;T. Nagamatsu;Y. Suzuki
我们研究了TJ-8014的抗肾炎作用，与潘生丁相比，对新月体型抗GBM肾炎大鼠。当从异源期（从抗GBM血清注射后的第二天）开始施用测试药物时，TJ-8014以2.0 g/kg/天，p.o.，显著抑制尿蛋白排泄和血浆胆固醇和尿素氮水平的升高以及肾小球组织病理学变化（即，新月体形成、粘附和纤维素样坏死）。TJ-8014，0.1和0.5 g/kg/天，p.o.，和潘生丁0.4g/天，口服，仅抑制组织病理学变化。当从疾病建立后的自体阶段（从抗GBM血清注射后第22天）开始治疗时，仅口服5.0 g/kg/天的高剂量TJ-8014，在第53天评估，有效改善已建立的肾炎的组织病理学变化。小剂量TJ-8014和潘生丁无效。这些结果表明，TJ-8014可能是一种有用的日本草药对快速进行性肾小球肾炎，其特征是严重的肾小球病变与广泛的新月体的形成。此外，将讨论这种药物的作用机制。
We investigated the antinephritic effects of TJ-8014, in comparison to dipyridamole, on crescentic-type anti-GBM nephritis in rats. When administration of test drugs was started from the heterologous phase (from the day after the anti-GBM serum injection), TJ-8014 at 2.0 g/kg/day, p.o., markedly inhibited the urinary protein excretion and elevations of plasma cholesterol and urea nitrogen levels as well as glomerular histopathological changes (i.e., crescent formation, adhesion and fibrinoid necrosis) throughout the 40-day observation period. TJ-8014 at 0.1 and 0.5 g/kg/day, p.o., and dipyridamole at 0.4 g/day, p.o., inhibited only the histopathological changes. When treatment was started from the autologous phase (from the 22nd day after the anti-GBM serum injection) after the disease had been established, only the high dose of 5.0 g/kg/day of TJ-8014, p.o., was effective in improving the histopathological changes of the established nephritis, as assessed on the 53rd day. The low doses of TJ-8014 and dipyridamole were ineffective. These results suggest that TJ-8014 may be a useful Japanese herbal medicine against rapidly progressive glomerulonephritis, which is characterized by severe glomerular lesions with the extensive formation of crescents. Furthermore, the mechanisms of action of this medicine will be discussed.
前列腺素 E 抑制抗体合成作为预防小鼠免疫复合物肾小球肾炎的机制。
DOI：
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发表时间：
1982
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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作者：
McLeish,KR;Gohara,AF;Gunning3rd,WT
通讯作者：
Gunning3rd,WT