More than 50 long-term effects of COVID-19: a systematic review and meta-analysis.

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis.
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COVID-19 的 50 多种长期影响:系统回顾和荟萃分析。

DOI:
10.1038/s41598-021-95565-8
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发表时间:
2021-08-09
期刊:
影响因子:
4.6
通讯作者:
Villapol S
Villapol S
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Lopez-Leon S;Wegman-Ostrosky T;Perelman C;Sepulveda R;Rebolledo PA;Cuapio A;Villapol S

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COVID-19可能涉及持续性、后遗症和其他医疗并发症,这些并发症在最初康复后持续数周至数月。本系统性综述和荟萃分析旨在识别评估COVID-19长期影响的研究。检索LitCOVID和Embase,以识别2021年1月1日之前发表的原始数据文章,至少100例患者。对于两项或多项研究中报告的效应,使用MetaXL软件使用随机效应模型进行荟萃分析,以估计合并患病率和95% CI。遵循PRISMA指南。共识别出18,251篇出版物,其中15篇符合纳入标准。估计了55种长期效应的患病率,进行了21项荟萃分析,纳入了47,910例患者(年龄17-87岁)。纳入的研究将长期COVID定义为病毒感染后14至110天。据估计,80%的SARS-CoV-2感染患者会出现一种或多种长期症状。最常见的五种症状是疲劳(58%)、头痛(44%)、注意力障碍(27%)、脱发(25%)和呼吸困难(24%)。多学科团队对于制定预防措施、康复技术和临床管理策略至关重要,这些策略具有全患者视角,旨在解决COVID-19长期护理问题。
COVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles with original data published before the 1st of January 2021, with a minimum of 100 patients. For effects reported in two or more studies, meta-analyses using a random-effects model were performed using the MetaXL software to estimate the pooled prevalence with 95% CI. PRISMA guidelines were followed. A total of 18,251 publications were identified, of which 15 met the inclusion criteria. The prevalence of 55 long-term effects was estimated, 21 meta-analyses were performed, and 47,910 patients were included (age 17–87 years). The included studies defined long-COVID as ranging from 14 to 110 days post-viral infection. It was estimated that 80% of the infected patients with SARS-CoV-2 developed one or more long-term symptoms. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). Multi-disciplinary teams are crucial to developing preventive measures, rehabilitation techniques, and clinical management strategies with whole-patient perspectives designed to address long COVID-19 care.
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