TRIHYDROXYTETRAENES - A NOVEL SERIES OF COMPOUNDS FORMED FROM ARACHIDONIC-ACID IN HUMAN-LEUKOCYTES
TRIHYDROXYTETRAENES - A NOVEL SERIES OF COMPOUNDS FORMED FROM ARACHIDONIC-ACID IN HUMAN-LEUKOCYTES
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DOI：
10.1016/0006-291x(84)91486-4
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发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
SAMUELSSON, B
中科院分区：
文献类型：
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作者：
SERHAN, CN;HAMBERG, M;SAMUELSSON, B
15-HPETE（15-HPETE）与人白细胞的加成反应，生成了一系列新的含4个共轭双键的化合物。四烯的产率增加了约40%。100-当离子载体A23187（5 μ M）与15-HPETE同时加入时，通过物理方法和化学降解确定了主要四烯的结构，发现其为5，6，15 L-三羟基-7，9，11，13-二十碳四烯酸。
Addition of 15L-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) to human leukocytes led to the formaton of a novel series of compounds containing 4 conjugated double bonds. The yield of tetraenes was increased .apprx. 100-fold when ionophore A23187 (5 .mu.M) was added simultaneously with 15-HPETE. The structure of the major tetraene was established by physical methods as well as by chemical degradation and found to be 5,6,15L-trihydroxy-7,9,11,13-eicosatetraenoic acid.