ACCUMULATION OF N-ACYLETHANOLAMINE GLYCEROPHOSPHOLIPIDS IN INFARCTED MYOCARDIUM
ACCUMULATION OF N-ACYLETHANOLAMINE GLYCEROPHOSPHOLIPIDS IN INFARCTED MYOCARDIUM
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DOI：
10.1016/0005-2760(80)90260-x
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
SCHMID, HHO
中科院分区：
文献类型：
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作者：
EPPS, DE;NATARAJAN, V;SCHMID, HHO
结扎冠状动脉左降支后24小时，在犬心肌梗塞区域检测到新的磷脂。梗塞的中心和周边区域含有大量的这种脂质（脂质 P 的 4-6%），但它不存在于同一组织的明显正常部分。通过红外光谱、化学降解以及与合成和半合成标准品的比较来分离和表征脂质。它被鉴定为由二酰基-、烷-1-烯酰基-和烷基酰基甘油物质组成的N-酰基乙醇胺甘油磷脂的混合物。 N-酰基主要为16:0和18:0，少量为18:1和18:2。梗塞区域乙醇胺甘油磷脂的相对减少及其分子种类的相似性表明这些磷脂之间存在前体-产物关系。 [哺乳动物心肌表现出高代谢活性，主要依赖脂肪酸提供能量，并且需要大量的 O2 才能发挥正常功能。]
A new phospholipid was detected in the infarcted areas of canine myocardium 24 h after ligation of the left descending branch of the coronary artery. The central and peripheral areas of the infarct contained significant amounts of this lipid (4-6% of lipid P), but it was not present in the apparently normal portions of the same tissue. The lipid was isolated and characterized by its IR spectrum, by chemical degradation and by comparison with synthetic and semi-synthetic standards. It was identified as a mixture of N-acylethanolamine glycerophospholipids consisting of diacyl-, alk-1-enylacyl- and alkylacylglycerol species. The N-acyl groups were mainly 16:0 and 18:0 with smaller proportions of 18:1 and 18:2. The relative decrease of ethanolamine glycerophospholipids in the infarcted areas and the similarity in their molecular species suggests a precursor-product relationship between these phospholipids. [Mammalian cardiac muscle exhibits high metabolic activity, is dependent predominantly on fatty acids for energy and requires a high amount of O2 for normal function.].