T2 measurements of cartilage in osteoarthritis patients with meniscal tears.
T2 measurements of cartilage in osteoarthritis patients with meniscal tears.
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DOI：
10.2214/ajr.08.2256
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发表时间：
2009-11
期刊：
影响因子：
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通讯作者：
Regatte R
中科院分区：
文献类型：
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作者：
Friedrich KM;Shepard T;de Oliveira VS;Wang L;Babb JS;Schweitzer M;Regatte R
本研究的目的是通过 T2 映射定量评估软骨退变，以比较有和没有半月板撕裂的患者。使用 2D 多回波自旋回波序列进行 T2 映射，对 37 名具有骨关节炎临床症状的患者（18 名男性，平均年龄 ± SD，65.7 ± 7.8 岁；19 名女性，平均年龄，63.8 ± 12.0 岁）进行 3-T MRI 研究。半月板信号和形态进行定性分级并与软骨的 T2 值相关。采用协方差分析、Bonferroni 多重比较校正和 Spearman 相关系数进行统计分析。半月板撕裂的患者（中位±四分位距，50.1±6.1毫秒）的软骨T2值显着（p = 0.021）高于没有半月板撕裂的患者（45.7±4.8毫秒）。内侧半月板撕裂患者的内侧间室软骨 T2 值显着高于外侧间室 (p = 0.018)。半月板撕裂患者的 T2 测量值增加；这一发现进一步支持了骨关节炎与半月板和透明软骨损伤相关的理论。
The objective of this study was to quantitatively assess cartilage degeneration via T2 mapping to compare patients with and those without meniscal tears. Thirty-seven patients (18 men, mean age ± SD, 65.7 ± 7.8 years; 19 women, mean age, 63.8 ± 12.0 years) with clinical symptoms of osteoarthritis were studied on 3-T MRI using a 2D multiecho spin-echo sequence for T2 mapping. Meniscal signal and morphology were qualitatively graded and correlated to the T2 values of cartilage. Analysis of covariance, Bonferroni multiple comparison correction, and Spearman’s correlation coefficients were used for statistical analysis. Patients with meniscal tears (median ± interquartile range, 50.1 ± 6.1 milliseconds) had significantly (p = 0.021) higher T2 values of cartilage than those without meniscal tears (45.7 ± 4.8 milliseconds). T2 values of cartilage were significantly higher in the medial compartment than in the lateral compartment in patients with medial meniscal tears (p = 0.018). T2 measurements are increased in patients with meniscal tears; this finding adds support to the theory of an association of osteoarthritis with damage to both the menisci and hyaline cartilage.