The Risk of Necrotizing Enterocolitis Differs Among Preterm Pigs Fed Formulas With Either Lactose or Maltodextrin
The Risk of Necrotizing Enterocolitis Differs Among Preterm Pigs Fed Formulas With Either Lactose or Maltodextrin
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DOI：
10.1097/mpg.0000000000001707
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发表时间：
2018-03-01
影响因子：
2.9
通讯作者：
Buddington, Karyl K.
中科院分区：
文献类型：
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作者：
Buddington, Randal K.;Davis, Samantha L.;Buddington, Karyl K.
目的：当早产儿无法获得母乳时，需要不会增加坏死性小肠结肠炎(NEC)风险的配方奶粉。在配方中加入新的成分来降低NEC在临床上并不有效。取而代之的是，我们测试了通过去除早产配方中现在包含的麦芽糊精可以降低NEC的预测。方法：使用自发性NEC的早产猪模型来评估6-7天的喂养配方相同的生长、健康和肠道反应，除了碳水化合物的来源；无论是100%的乳糖还是麦芽糊精；以初乳为对照。结果：含有麦芽糊精的配方导致NEC的发病率为50%，死亡率为30%。乳糖配方奶和初乳导致NEC的发生率为0%。添加乳糖的猪生长最快，添加麦芽糊精的猪生长次之，饲喂牛初乳的猪生长最差(P
Objectives: When breast milk is unavailable for preterm infants, formulas are needed that won't increase the risk of necrotizing enterocolitis (NEC). Adding novel ingredients to formula to reduce NEC has not been effective clinically. Instead, we tested the prediction that NEC can be reduced by removing the maltodextrin now included in preterm formulas.Methods: The preterm pig model of spontaneous NEC was used to evaluate growth, health, and intestinal responses to 6 to 7 days of feeding formulas that were identical except for the source of carbohydrate; either 100% lactose or maltodextrin; colostrum was used as the control.Results: Formula with maltodextrin resulted in a 50% incidence of NEC with 30% mortality. The lactose formula and colostrum resulted in a 0% incidence of NEC. Growth was highest for pigs fed the formula with lactose, intermediate with maltodextrin, and minimal when bovine colostrum was fed (P