A Randomized Clinical Trial of Three Options for N95 Respirators and Medical Masks in Health Workers
A Randomized Clinical Trial of Three Options for N95 Respirators and Medical Masks in Health Workers
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DOI：
10.1164/rccm.201207-1164oc
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发表时间：
2013-05-01
影响因子：
24.7
通讯作者：
Dwyer, Dominic E.
中科院分区：
文献类型：
--
作者：
MacIntyre, C. Raina;Wang, Quanyi;Dwyer, Dominic E.
目的：对2009- 2010年冬季北京市1，669名医护人员进行随机分组临床试验。方法：在进行高风险手术或屏障护理时，随机选择医用口罩、N95呼吸器或靶向使用N95呼吸器。结果包括临床呼吸道疾病（CRI）和实验室确认的呼吸道病原体在有症状的受试者。测量和主要结果：CRI率最高的是医用口罩组（98/572; 17%），其次是目标N95组（61/516; 11.8%）和N95组（42/581; 7.2%）（P
Rationale We compared three policy options for the use of medical masks and N95 respirators in healthcare workers (HCWs).Objectives: A cluster randomized clinical trial of 1,669 hospital-based HCWs in Beijing, China in the winter of 2009-2010.Methods: Participants were randomized to medical masks, N95 respirators, or targeted use of N95 respirators while doing high-risk procedures or barrier nursing. Outcomes included clinical respiratory illness (CRI) and laboratory-confirmed respiratory pathogens in symptomatic subjects.Measurements and Main Results: The rate of CRI was highest in the medical mask arm (98 of 572; 17%), followed by the targeted N95 arm (61 of 516; 11.8%), and the N95 arm (42 of 581; 7.2%) (P