Assessment of neuropathic pain after spinal cord injury using quantitative pain drawings.
Assessment of neuropathic pain after spinal cord injury using quantitative pain drawings.
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DOI：
10.1038/s41393-021-00616-6
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发表时间：
2021-05
期刊：
影响因子：
2.2
通讯作者：
Hubli M
中科院分区：
文献类型：
--
作者：
Rosner J;Lütolf R;Hostettler P;Villiger M;Clijsen R;Hohenauer E;Barbero M;Curt A;Hubli M
成人截瘫脊髓损伤(SCI)和神经病理性疼痛(NP)的临床横断面队列研究。目的：评估标准化量化疼痛描记在脊髓损伤后NP患者中的可靠性。瑞士苏黎世巴尔格里斯特大学医院脊髓损伤中心的医院研究机构。20名慢性胸髓损伤和神经病理性疼痛的患者从国家和地方脊髓损伤登记中招募。进行了全面的临床检查和疼痛评估。在随后的时间点，相隔13天(IQR 7.8-14.8)获得疼痛描述图，以评估重测的可靠性。自发性NP的平均幅度为11.3%(IQR4.9~35.8)，强度平均为5(IQR3~7)。疼痛程度显示出极好的组间可靠性(组内相关系数为0.96)。以轻触和针刺感量化的感觉丧失与较大的疼痛程度相关(rpinprick = −为0.47，p = 为0.04；rlight Touch = −为0.64，p <； 为0.01)。在人类脊髓损伤中，使用定量疼痛描记来评估疼痛程度是非常可行和可靠的。将感觉缺陷的信息与疼痛的存在联系起来，可能为脊髓损伤后感觉去传入与神经病理性疼痛的发展之间的相互作用提供独特的见解。
Clinimetric cross-sectional cohort study in adults with paraplegic spinal cord injury (SCI) and neuropathic pain (NP). To assess the reliability of standardized quantitative pain drawings in patients with NP following SCI. Hospital-based research facility at the Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland. Twenty individuals with chronic thoracic spinal cord injury and neuropathic pain were recruited from a national and local SCI registry. A thorough clinical examination and pain assessments were performed. Pain drawings were acquired at subsequent timepoints, 13 days (IQR 7.8–14.8) apart, in order to assess test-retest reliability. The average extent [%] and intensity [NRS 0–10] of spontaneous NP were 11.3% (IQR 4.9–35.8) and 5 (IQR 3–7), respectively. Pain extent showed excellent inter-session reliability (intraclass correlation coefficient 0.96). Sensory loss quantified by light touch and pinprick sensation was associated with larger pain extent (rpinprick = −0.47, p = 0.04; rlight touch = −0.64, p < 0.01). Assessing pain extent using quantitative pain drawings is readily feasible and reliable in human SCI. Relating information of sensory deficits to the presence of pain may provide distinct insights into the interaction of sensory deafferentation and the development of neuropathic pain after SCI.