Effects of cannabinoids on neurotransmission.
Effects of cannabinoids on neurotransmission.
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大麻素对神经传递的影响。
DOI：
--
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发表时间：
2005
影响因子：
--
通讯作者：
E. Schlicker
中科院分区：
文献类型：
--
作者：
Bela Szabo;E. Schlicker
CB 1大麻素受体广泛分布于中枢和外周神经系统。在神经元内，CB 1受体通常位于轴突末梢，其激活导致抑制递质释放。其结果是通过突触前机制抑制神经传递。已在中枢神经系统的许多区域观察到对多巴胺能、GABA能、甘氨酸能、胆碱能、去甲肾上腺素能和多巴胺能神经传递的抑制。在外周神经系统中，经常观察到CB 1受体介导的肾上腺素能、胆碱能和感觉神经效应传递的抑制。CB 1受体介导的突触前抑制的普遍存在的操作的特征是功能系统的拮抗成分（例如，同一神经元的兴奋性和抑制性输入）同时被大麻素抑制。抑制电压依赖性钙通道、激活钾通道和直接干扰突触囊泡释放机制都与大麻素诱发的递质释放抑制有关。许多突触前CB 1受体受到内源性紧张，即它们是组成性活性的和/或被内源性大麻素连续激活。与大麻素对突触前抑制的丰富数据相比，大麻素对原位神经元的体腺样体部分的作用的例子很少。
The CB1 cannabinoid receptor is widely distributed in the central and peripheral nervous system. Within the neuron, the CB1 receptor is often localised in axon terminals, and its activation leads to inhibition of transmitter release. The consequence is inhibition of neurotransmission via a presynaptic mechanism. Inhibition of glutamatergic, GABAergic, glycinergic, cholinergic, noradrenergic and serotonergic neurotransmission has been observed in many regions of the central nervous system. In the peripheral nervous system, CB1 receptor-mediated inhibition of adrenergic, cholinergic and sensory neuroeffector transmission has been frequently observed. It is characteristic for the ubiquitous operation of CB1 receptor-mediated presynaptic inhibition that antagonistic components of functional systems (for example, the excitatory and inhibitory inputs of the same neuron) are simultaneously inhibited by cannabinoids. Inhibition of voltage-dependent calcium channels, activation of potassium channels and direct interference with the synaptic vesicle release mechanism are all implicated in the cannabinoid-evoked inhibition of transmitter release. Many presynaptic CB1 receptors are subject to an endogenous tone, i.e. they are constitutively active and/or are continuously activated by endocannabinoids. Compared with the abundant data on presynaptic inhibition by cannabinoids, there are only a few examples for cannabinoid action on the somadendritic parts of neurons in situ.
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影响因子：
2.5
作者：
W. Twitchell;Sean P. Brown;K. Mackie
通讯作者：
W. Twitchell;Sean P. Brown;K. Mackie
DOI：
--
发表时间：
1995-05
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
S. Deadwyler;R. Hampson;J. Mu;A. Whyte;S. Childers
通讯作者：
S. Deadwyler;R. Hampson;J. Mu;A. Whyte;S. Childers
Delta9-四氢大麻酚作为部分激动剂调节培养物中大鼠海马神经元之间的谷氨酸突触传递。
影响因子：
3.6
作者：
Shen,M;Thayer,SA
通讯作者：
Thayer,SA
大麻素 CB(1) 受体激动剂会导致小鼠小脑功能障碍。
DOI：
--
发表时间：
2001
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Patel,S;Hillard,CJ
通讯作者：
Hillard,CJ
影响因子：
15.9
作者：
Deutsch, DG;Goligorsky, MS;Moore, LC
通讯作者：
Moore, LC