Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations
Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations
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DOI：
10.3892/etm.2011.266
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发表时间：
2011-07-01
影响因子：
2.7
通讯作者：
Yamada, Yoshiji
中科院分区：
文献类型：
--
作者：
Fujimaki, Tetsuo;Kato, Kimihiko;Yamada, Yoshiji
我们先前通过全基因组关联研究确定BTn2A1基因(BTN2A1)是日本人心肌梗死的易感基因rs6929846。鉴于血脂异常是心肌梗死的重要危险因素，本研究旨在探讨日本和韩国人群中BTN2A1基因rs6929846多态与血脂异常的关系。共有来自三个独立主题小组的10,953名个人接受了检查。检测BTN2A1基因rs6929846多态性与血清甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇浓度的关系。在日本受试者A组(P=0.0004)、B组(P=0.0010)和韩国人组(P=0.0095)中，BTN2A1基因C-T多态(Rs6929846)与血清甘油三酯浓度显著相关，T等位基因与血清甘油三酯浓度升高相关。在日本受试者A组(P=0.0047)和B组(P=0.001.5)中，rs6929846与血清高密度脂蛋白-胆固醇浓度相关，T等位基因与血清高密度脂蛋白-胆固醇浓度降低有关，但在韩国人群中不相关。该基因多态性仅在日本受试者B组中与低密度脂蛋白-胆固醇浓度相关(P=0.0059)，T等位基因与低密度脂蛋白-胆固醇浓度升高有关。提示BTN2A1可能是东亚人群高甘油三酯血症和日本人群低高密度脂蛋白血症的易感基因。
We previously identified rs6929846 of the butyrophilin, subfamily 2, member Al gene (BTN2A1) as a susceptibility locus for myocardial infarction in Japanese individuals by a genome-wide association study. The aim of the present study was to examine the relation of the rs6929846 polymorphism of BTN2A1 to dyslipidemia in Japanese and Korean populations, given that clyslipidemia is an important risk factor for myocardial infarction. A total of 10,953 individuals from three independent subject panels were examined. The relations of the rs6929846 polymorphism of BTN2A1 to serum concentrations of triglycerides, high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol were examined in each subject panel. The C T polymorphism (rs6929846) of BTN2A1 was significantly associated with serum concentrations of triglycerides in Japanese subject panels A (P=0.0004) and B (P=0.0010), and in the Korean population (P=0.0095), with the minor T allele being related to an increased serum concentration of triglycerides. The rs6929846 was associated with serum concentrations of HDL-cholesterol in Japanese subject panels A (P=0.0047) and B (P=0.001.5), with the T allele being related to a decreased serum concentration of HDL-cholesterol, but not in the Korean population. This polymorphism was associated with the serum concentration of LDL-cholesterol only in Japanese subject panel B (P=0.0059), with the T allele being related to an increased serum concentration of LDL-cholesterol. The results suggest that BTN2A1 may be a susceptibility gene for hypertriglyceridemia in East Asian populations and for low serum HDL-cholesterol in the Japanese population.