The Bacillus subtilis transition state regulator AbrB binds to the-35 promoter region of comK
The Bacillus subtilis transition state regulator AbrB binds to the-35 promoter region of comK
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DOI：
10.1111/j.1574-6968.2003.tb11532.x
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发表时间：
2003-01-28
影响因子：
2.1
通讯作者：
Serror, P
中科院分区：
文献类型：
--
作者：
Hamoen, LW;Kausche, D;Serror, P
遗传感受态是枯草芽孢杆菌在营养缺乏条件下启动的一个分化过程，受一个复杂的信号转导级联控制。comK的启动子编码感受态转录因子，受至少四种不同转录因子的调节：Rok、CodY、DegU和ComK本身。遗传数据表明，comK的表达也受到过渡态调节因子AbrB的影响。在本文中，我们表明，AbrB特异性结合到comK启动子，并覆盖RNA聚合酶结合位点，使其成为第五个转录因子调节的comK启动子的活性。(C)2002年，欧洲微生物学会联合会。由Elsevier Science B.V.出版，版权所有。
Genetic competence is a differentiation process initiated by Bacillus subtilis as a result of nutritional deprivation, and is controlled by a complex signal transduction cascade. The promoter of comK, encoding the competence transcription factor, is regulated by at least four different transcription factors: Rok, CodY, DegU and ComK itself. Genetic data have shown that comK expression is influenced by the transition state regulator AbrB as well. In this paper we show that AbrB binds specifically to the comK promoter and covers the RNA polymerase binding site, making it the fifth transcription factor regulating the activity of the comK promoter. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.