Advances in potential M-protein peptide-based vaccines for preventing rheumatic fever and rheumatic heart disease
Advances in potential M-protein peptide-based vaccines for preventing rheumatic fever and rheumatic heart disease
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DOI：
10.1385/ir:35:3:233
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发表时间：
2006-10-01
影响因子：
4.4
通讯作者：
Good, Michael F.
中科院分区：
文献类型：
--
作者：
Batzloff, Michael R.;Pandey, Manisha;Good, Michael F.
风湿热（RF）和风湿性心脏病（RHD）是革兰氏阳性菌化脓性链球菌（也称为A组链球菌，GAS）感染（或反复感染）的感染后并发症。生殖器缺陷和生殖器出血是全球性问题，影响到发达国家和许多发展中国家的许多土著居民。然而，RF和RHD只是由这种生物体引起的更大疾病谱的一部分。针对GAS的疫苗的开发主要针对称为M蛋白的丰富的细胞表面蛋白。本文综述了不同的M蛋白为基础的亚单位疫苗的方法和不同的交付技术用于管理这些疫苗候选人在临床前研究。
Rheumatic fever (RF) and rheumatic heart disease (RHD) are post-infectious complications of an infection (or repeated infection) with the Gram-positive bacterium, Streptococcus pyogenes (also known as group A streptococcus, GAS). RF and RHD are global problems and affect many indigenous populations of developed countries and many developing countries. However, RF and RHD are only part of a larger spectrum of diseases caused by this organism. The development of a vaccine against GAS has primarily targeted the abundant cell-surface protein called the M-protein. This review focuses on different M-protein-based-subunit vaccine approaches and the different delivery technologies used to administer these vaccine candidates in preclinical studies.