Proteomics of the human placenta: Promises and realities
Proteomics of the human placenta: Promises and realities
复制标题
DOI：
10.1016/j.placenta.2007.12.005
复制
发表时间：
2008-02-01
期刊：
影响因子：
3.8
通讯作者：
Vandre, D. D.
中科院分区：
文献类型：
--
作者：
Robinson, J. M.;Ackerman, W. E.;Vandre, D. D.
蛋白质组学是一个研究领域，其最终目标是对感兴趣的生物系统中表达的所有蛋白质进行全局分析。然而，技术限制目前阻碍了复杂系统的蛋白质组范围分析。从更实际的意义上来说，蛋白质组学研究的期望结果是将大型蛋白质数据集转换为提供有关临床状况的有意义信息的格式（例如，用作疾病的诊断和/或预后指标的生物标志物）。在这里，我们通过描述现有研究来讨论胎盘蛋白质组学，指出它们的优点和缺点。在此过程中，我们努力让对该研究领域感兴趣的研究人员了解目前双曲线承诺与现实之间的差距。此外，我们还讨论了蛋白质组学在基于发现的研究中的效用，特别是在挖掘胎盘生物学新见解的能力方面。重要的是，当考虑正在研究的系统，例如人类胎盘和与胎盘功能异常相关的疾病时，蛋白质组学可以作为获取传统方法不可能获得的信息的强大“捷径”。 (C) 2008 Elsevier Ltd. 保留所有权利。
Proteomics is an area of study that sets as its ultimate goal the global analysis of all of the proteins expressed in a biological system of interest. However, technical limitations currently hamper proteome-wide analyses of complex systems. In a more practical sense, a desired outcome of proteomics research is the translation of large protein data sets into formats that provide meaningful information regarding clinical conditions (e.g., biomarkers to serve as diagnostic and/or prognostic indicators of disease). Herein, we discuss placental proteomics by describing existing studies, pointing out their strengths and weaknesses. In so doing, we strive to inform investigators interested in this area of research about the current gap between hyperbolic promises and realities. Additionally, we discuss the utility of proteomics in discovery-based research, particularly as regards the capacity to unearth novel insights into placental biology. Importantly, when considering under studied systems such as the human placenta and diseases associated with abnormalities in placental function, proteomics can serve as a robust 'shortcut' to obtaining information unlikely to be garnered using traditional approaches. (C) 2008 Elsevier Ltd. All rights reserved.