Association between Quantitative Lower Limb Arterial Calcification and Bilateral Severe Knee Osteoarthritis.
Association between Quantitative Lower Limb Arterial Calcification and Bilateral Severe Knee Osteoarthritis.
复制标题
定量下肢动脉钙化与双侧严重膝骨关节炎之间的关联。
DOI：
10.1080/14397595.2020.1868120
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发表时间：
2021
期刊：
影响因子：
2.2
通讯作者：
Matsuda S.
中科院分区：
文献类型：
--
作者：
Yoshida S;Nishitani K;Yamamoto Y;Ito H;Saito M;Morita Y;Nakamura S;Kuriyama S;Matsuda S.
目的 探讨使用计算机断层扫描 (CT) 量化的下肢动脉钙化 (LLAC) 是否是双侧严重膝骨关节炎 (OA) 的危险因素。方法这项横断面研究包括计划接受手术治疗的原发性膝内翻 OA 的患者。使用 Kellgren-Lawrence (KL) 分级评估膝关节 OA，KL 3 级和 4 级定义为严重 OA。定量测量双侧全腿CT中的LLAC评分，并根据中值分为低组和高组。使用改良的泊松回归模型来检查分类 LLAC 评分与双侧严重膝关节 OA 之间的关系，并调整可能的混杂因素。结果在总共检查的 252 名患者中，多变量改良泊松回归分析显示较高的 LLAC 评分与双侧严重膝关节 OA 之间存在显着相关性（调整后的风险比 = 1.28；95% 置信区间 [CI]， 1.12–1.48；p< .001)。在男性和高 LLAC 之间观察到显着的交互作用（交互作用 p= .03）。结论 LLAC 与双侧严重膝关节 OA 相关，LLAC 评分可能是识别双侧严重膝关节 OA 风险患者的有用测量方法。
ObjectivesTo investigate whether lower limb arterial calcification (LLAC) quantified using computed tomography (CT) was a risk factor for bilateral severe knee osteoarthritis (OA).MethodsThis cross-sectional study included patients who were scheduled for surgical treatment of primary varus knee OA. Knee OA was evaluated using the Kellgren-Lawrence (KL) classification, KL grades 3 and 4 were defined as severe OA. The LLAC score in the bilateral whole leg CT was quantitatively measured and categorized into low or high groups based on the median value. A modified Poisson regression model was used to examine the relationship between the categorized LLAC score and the presence of bilateral severe knee OA with adjustment for possible confounders.ResultsOf a total of 252 patients examined, multivariable modified Poisson regression analysis showed a significant association between higher LLAC score and the presence of bilateral severe knee OA (adjusted risk ratio = 1.28; 95% confidence interval [CI], 1.12–1.48;p< .001). A substantial interaction was observed between male sex and high LLAC (pfor interaction = .03).ConclusionLLAC was associated with bilateral severe knee OA, and the LLAC score may be a useful measurement to identify patients at risk of bilateral severe knee OA.