Feasibility of perfusion and early-uptake F-18-FDG PET/CT in primary hepatocellular carcinoma: a dual-input dual-compartment uptake model
Feasibility of perfusion and early-uptake F-18-FDG PET/CT in primary hepatocellular carcinoma: a dual-input dual-compartment uptake model
复制标题
原发性肝细胞癌灌注和早期摄取 F-18-FDG PET/CT 的可行性：双输入双室摄取模型
DOI：
10.1007/s11604-021-01140-6
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发表时间：
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影响因子：
2.1
通讯作者：
He Jianfeng
中科院分区：
文献类型：
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作者：
Wang Shaobo;Li Boqiao;Li Pengfei;Xie Ran;Wang Quanshi;Shi Hong;He Jianfeng
目的pet可以同时评估灌注状态和代谢活动。我们的目的是评估灌注和早期摄取18f - fdg PET/CT在肝细胞癌（HCC）中的可行性，采用双输入双室摄取模型。材料与方法回顾性收集17例病理诊断的hcc患者5分钟动态PET/CT和常规PET/CT扫描数据。计算肝动脉血流（Fa）、门静脉血流（Fv）、总血流量(F)、肝动脉灌注指数（HPI）、门静脉灌注指数（PPI）、血容量（BV）、细胞外平均传递时间（MTT）、细胞内摄取率（Ki）等参数。生成Fa、HPI、mttp和kiimages并用于HCC的识别。结果与周围肝组织比较，hcc与周围肝组织相比，inFa、HPI、ki和最大标准摄取值（SUVmax）显著升高（P< 0.001）， inFv（P< 0.05）和ppi （P< 0.001）显著降低（P< 0.05）， f、BVandMTT（P< 0.05）无显著差异。灌注和早期摄取PET/CT使hcc阳性率由单纯常规PET/CT的52.9%提高到联合PET/CT的88.2% （P< 0.05）。结论灌注和早期摄取PET/CT对HCC的诊断是可行的，可提供额外的功能信息，提高诊断效能。
PurposePET enables a concurrent evaluation of perfusion status and metabolic activity. We aimed to evaluate the feasibility of perfusion and early-uptake18F-FDG PET/CT in hepatocellular carcinoma (HCC) using a dual-input dual-compartment uptake model.Materials and methodsData from 5 min dynamic PET/CT and conventional PET/CT scans were retrospectively collected from 17 pathologically diagnosed HCCs. Parameters such as hepatic arterial blood flow (Fa), portal vein blood flow (Fv), total blood flow (F), hepatic arterial perfusion index (HPI), portal vein perfusion index (PPI), blood volume (BV), extracellular mean transit time (MTT) and intracellular uptake rate (Ki) were calculated.Fa,HPI,MTTandKiimages were generated and used to identify HCC.ResultsCompared with the surrounding liver tissue, HCCs showed significant increases inFa,HPI,Kiand the maximum standard uptake value (SUVmax) (allP< 0.001) and significant reductions inFv(P< 0.05) andPPI(P< 0.001).F,BVandMTT(allP> 0.05) did not differ significantly between HCCs and the surrounding liver tissue. Perfusion and early-uptake PET/CT increased the positivity rate of HCCs from 52.9% with conventional PET/CT alone to 88.2% with the combined method (P< 0.05).ConclusionsPerfusion and early-uptake PET/CT are feasible for diagnosing HCC and provide added functional information to enhance diagnostic performance.