A novel cortico-intrathalamic circuit for flight behavior
A novel cortico-intrathalamic circuit for flight behavior
复制标题
一种用于飞行行为的新型皮质-丘脑内回路
DOI：
10.1038/s41593-019-0391-6
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发表时间：
2019-06-01
影响因子：
25
通讯作者：
Li, Xiao-Ming
中科院分区：
文献类型：
--
作者：
Dong, Ping;Wang, Hao;Li, Xiao-Ming
逃跑是对即将到来的威胁的一种主动恐惧反应，它依赖于大脑皮层对感觉信息的快速风险评估。丘脑网状核（TRN）过滤皮质和丘脑之间的信息，但它是否参与飞行行为的调节仍然是未知的。在这里，我们报告说，激活小清蛋白表达神经元的边缘TRN，但不是那些在感觉TRN，介导飞行。来自扣带皮层（Cg）的谷氨酸能输入选择性地激活边缘TRN，这反过来又抑制丘脑背中间核（IMD）。这个Cg→边缘TRN→IMD回路的激活导致IMD的抑制并产生飞行行为。相反，去除对IMD的抑制会导致更多的冻结和更少的飞行，这表明IMD可能起着促冻结中心的作用。总体而言，这些发现揭示了通过TRN控制飞行反应的新型皮质丘脑回路。
Flight, an active fear response to imminent threat, is dependent on the rapid risk assessment of sensory information processed by the cortex. The thalamic reticular nucleus (TRN) filters information between the cortex and the thalamus, but whether it participates in the regulation of flight behavior remains largely unknown. Here, we report that activation of parvalbumin-expressing neurons in the limbic TRN, but not those in the sensory TRN, mediates flight. Glutamatergic inputs from the cingulate cortex (Cg) selectively activate the limbic TRN, which in turn inhibits the intermediodorsal thalamic nucleus (IMD). Activation of this Cg→limbic TRN→IMD circuit results in inhibition of the IMD and produces flight behavior. Conversely, removal of inhibition onto the IMD results in more freezing and less flight, suggesting that the IMD may function as a pro-freeze center. Overall, these findings reveal a novel corticothalamic circuit through the TRN that controls the flight response.