Determination of bisphenol A in river water and body fluid samples by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry
Determination of bisphenol A in river water and body fluid samples by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry
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DOI：
10.1016/j.jchromb.2004.02.005
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发表时间：
2004-06-05
影响因子：
3
通讯作者：
Nakazawa, H
中科院分区：
文献类型：
--
作者：
Kawaguchi, M;Inoue, K;Nakazawa, H
建立了搅拌棒吸附萃取（SBSE）原位衍生-热脱附（TD）-气相色谱-质谱（GC-MS）联用测定河水、尿液、血浆和唾液中痕量双酚A（BPA）的方法。考察了乙酸酐衍生化条件、样品体积、萃取时间等SBSE条件。那在河水、尿液、血浆和唾液样品中BPA的检测限分别为1-5、20、100和20 pg ml（-1）（ppt）。BPA的校准显示为线性，相关系数>0.99。BPA的平均回收率均大于95%（R.S.D.）。< 10%），使用添加的替代标准物C-13（12）-双酚A进行校正。这简单、准确、灵敏。选择性分析方法可用于液体样品中痕量BPA的测定。(C)2004 Elsevier B. V.保留所有权利。
A new method, based on stir bar sorptive extraction (SBSE) within situ derivatization and thermal desorption (TD)-gas chromatography-mass spectrometry (GC-MS) is described for the determination of trace amounts of bisphenol A (BPA) in river water, urine, plasma, and saliva samples. The derivatization conditions with acetic acid anhydride and the SBSE conditions such as sample volumes and extraction time are investigated. Then. the stir bar is subjected to TD followed by GC-MS. The detection limits of BPA in river water, urine, plasma, and saliva samples are 1-5, 20, 100, and 20 pg ml(-1) (ppt), respectively. Calibration for BPA was shown to be linear with a correlation coefficient of >0.99. The average recoveries of BPA in all samples are higher than 95% (R.S.D. < 10%) with correction using an added surrogate standard, C-13(12)-bisphenol A. This simple, accurate, sensitive. and selective analytical method may be applicable to the determination of trace amounts of BPA in liquid samples. (C) 2004 Elsevier B.V. All rights reserved.