Oxidative Stress in Cancer
Oxidative Stress in Cancer
复制标题
DOI：
10.1007/978-981-15-4501-6_126-1
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
U. H. Sk;S. Bhattacharya
中科院分区：
文献类型：
--
作者：
U. H. Sk;S. Bhattacharya
癌症涉及多种细胞和分子变化，将正常细胞转化为恶性细胞。活性氧在生命系统中作为生理性氧化还原信号信使。活性氧是不断形成的，被宿主的防御系统清除，两者之间存在平衡。当平衡失去时，系统进入一种称为氧化应激的状态。ROS/氧化应激在癌症的发生和发展过程中密切相关。硒是维持包括人类在内的哺乳动物系统正常生理过程所必需的一种微量元素。它是非常重要的硒酶的一部分。除了其抗氧化特性外，硒还参与癌症预防。它是一种非常有前途的癌症治疗剂，因为硒具有独特的性质，也具有促氧化能力。硒化合物可以作为标准化疗药物以及放射治疗的有效佐剂，以降低治疗毒性。但使用硒化合物的主要限制是有益剂量和毒性剂量之间的狭窄治疗窗口。纳米配方的硒已经出来作为一种替代用途，由于其降低毒性和specificity.In本书章硒化合物在其无机，有机形式以及其纳米配方在减少癌症的氧化应激的有益效果将进行讨论。
The disease cancer involves multiple cellular and molecular changes, which converts a normal cell into a malignant one. Reactive oxygen species acts as the physiological redox signaling messenger in the living system. ROS is formed continuously which is being removed by the host’s defense system and there is a balance between the two. When the balance is lost, the system enters in a state called oxidative stress. ROS/oxidative stress is involved intimately in cancer during its initiation and progress. Selenium is an essential trace element required for normal physiological process in mammalian system including human to maintain redox homeostasis. It is a part of very essential selenoenzymes. Apart from its antioxidative properties, selenium is involved in cancer prevention. It is a very promising agent for cancer therapy also as selenium has the unique property to have pro oxidative power also. Selenium compounds can serve as an effective adjuvant with standard chemotherapeutic drug as well with radiation therapy to reduce the therapeutic toxicity. But the main limitation of using selenium compounds is the narrow therapeutic window between the beneficial dose and the toxic dose. Nano formulation of selenium has come out as an alternative use due to its reduced toxicity and specificity.In this book chapter the beneficial effect of selenium compounds in its inorganic, organic form as well as its nano formulation in reducing oxidative stress in cancer will be discussed.