Rhodium-catalyzed formylation of organomercurials: application to efficient polyol synthesis.
Rhodium-catalyzed formylation of organomercurials: application to efficient polyol synthesis.
复制标题
有机汞的铑催化甲酰化：在高效多元醇合成中的应用。
DOI：
10.1021/ol006393o
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发表时间：
2000
期刊：
影响因子：
5.2
通讯作者：
Leighton,JL
中科院分区：
文献类型：
--
作者：
Sarraf,ST;Leighton,JL
有机汞的铑催化还原反应是有机汞还原反应的一种新的转化反应。发现添加0.50当量的1，4-二氮杂双环[2.2.2]辛烷（DABCO）促进反应，并且推测DABCO充当汞的配体。几个例子来记录的反应的范围。该反应是在一个更大的程序的背景下开发的，该程序专注于开发用于合成多元醇衍生的天然产物的有效策略，并报道了采用该方法的Tolypothrixpentaether的有效（8步）合成。
The rhodium-catalyzed formylation of organomercurialsa new transformation of organomercurialsis reported. The addition of 0.50 equiv of 1,4-diazabicyclo[2.2.2]octane (DABCO) was found to promote the reaction, and it is postulated that the DABCO acts as a ligand for mercury. Several examples are presented to document the scope of the reaction. This reaction was developed in the context of a larger program focused on the development of efficient strategies for the synthesis of polyol-derived natural products, and an efficient (8 steps) synthesis ofTolypothrixpentaether that employs this methodology is reported.