Quantitative evaluation of carotid plaque composition by in vivo MRI
Quantitative evaluation of carotid plaque composition by in vivo MRI
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DOI：
10.1161/01.atv.0000149867.61851.31
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发表时间：
2005-01-01
影响因子：
8.7
通讯作者：
Yuan, C
中科院分区：
文献类型：
--
作者：
Saam, T;Ferguson, MS;Yuan, C
Objective - This study evaluates the ability of MRI to quantify all major carotid atherosclerotic plaque components in vivo.Methods and Results - Thirty-one subjects scheduled for carotid endarterectomy were imaged with a 1.5T scanner using time-of-flight -, T1-, proton density -, and T2-weighted images. A total of 214 MR imaging locations were matched to corresponding histology sections. For MRI and histology, area measurements of the major plaque components such as lipid-rich/necrotic core (LR/NC), calcification, loose matrix, and dense (fibrous) tissue were recorded as percentages of the total wall area. Intraclass correlation coefficients (ICCs) were computed to determine intrareader and inter-reader reproducibility. MRI measurements of plaque composition were statistically equivalent to those of histology for the LR/NC (23.7 versus 20.3%; P=0.1), loose matrix (5.1 versus 6.3%; P=0.1), and dense (fibrous) tissue (66.3% versus 64%; P=0.4). Calcification differed significantly when measured as a percentage of wall area (9.4 versus 5%; P
