Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer's disease.
Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer's disease.
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DOI：
10.1126/sciadv.abb0457
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发表时间：
2021-01
期刊：
影响因子：
13.6
通讯作者：
Wang YJ
中科院分区：
文献类型：
--
作者：
Liu YH;Wang J;Li QX;Fowler CJ;Zeng F;Deng J;Xu ZQ;Zhou HD;Doecke JD;Villemagne VL;Lim YY;Masters CL;Wang YJ
Aβ不同表位的NAB与阿尔茨海默病的严重程度和进展有不同的关联。阿尔茨海默病(AD)中自然产生的抗β-淀粉样蛋白抗体(NABS-Aβ)的病理相关性尚不清楚。我们的目的是在中国的横断面队列和澳大利亚成像、生物标记物和生活方式研究的纵向队列中，研究它们的水平及其与AD的β负担和认知功能下降的关系。根据其表位检测血浆和脑脊液中NABS-Aβ水平。AD患者脑脊液和血浆中针对Aβ氨基末端的NAB水平升高，而针对Aβ中段的NAB水平降低。针对Aβ氨基末端的较高的NAB水平和针对Aβ中域的较低的NAB水平与基线时较高的脑淀粉样变性和在随访中较快的认知功能下降相关。我们的发现提示适应性免疫系统在AD进展过程中的动态反应，并与当前的被动免疫治疗策略相关。
NAbs to different epitopes of Aβ are differentially associated with the severity and progression of Alzheimer’s disease. The pathological relevance of naturally occurring antibodies to β-amyloid (NAbs-Aβ) in Alzheimer’s disease (AD) remains unclear. We aimed to investigate their levels and associations with Aβ burden and cognitive decline in AD in a cross-sectional cohort from China and a longitudinal cohort from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. NAbs-Aβ levels in plasma and cerebrospinal fluid (CSF) were tested according to their epitopes. Levels of NAbs targeting the amino terminus of Aβ increased, and those targeting the mid-domain of Aβ decreased in both CSF and plasma in AD patients. Higher plasma levels of NAbs targeting the amino terminus of Aβ and lower plasma levels of NAbs targeting the mid-domain of Aβ were associated with higher brain amyloidosis at baseline and faster cognitive decline during follow-up. Our findings suggest a dynamic response of the adaptive immune system in the progression of AD and are relevant to current passive immunotherapeutic strategies.
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影响因子：
4.7
作者：
Deng J;Hou H;Giunta B;Mori T;Wang YJ;Fernandez F;Weggen S;Araki W;Obregon D;Tan J
通讯作者：
Tan J
DOI：
10.1186/s13195-017-0318-y
发表时间：
2017-12-08
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Ostrowitzki S;Lasser RA;Dorflinger E;Scheltens P;Barkhof F;Nikolcheva T;Ashford E;Retout S;Hofmann C;Delmar P;Klein G;Andjelkovic M;Dubois B;Boada M;Blennow K;Santarelli L;Fontoura P;SCarlet RoAD Investigators
通讯作者：
SCarlet RoAD Investigators
DOI：
10.1073/pnas.262663499
发表时间：
2002-12-24
影响因子：
11.1
作者：
Petkova, AT;Ishii, Y;Tycko, R
通讯作者：
Tycko, R
影响因子：
14.5
作者：
Brinkmalm, Gunnar;Hong, Wei;Walsh, Dominic M.
通讯作者：
Walsh, Dominic M.
影响因子：
9.9
作者：
Besong-Agbo, Daniela;Wolf, Elias;Dodel, Richard
通讯作者：
Dodel, Richard