DNA dumbbell tiles with uneven widths for 2D arrays
DNA dumbbell tiles with uneven widths for 2D arrays
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用于 2D 阵列的宽度不均匀的 DNA 哑铃块
DOI：
10.1039/c8ob02709a
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发表时间：
2019
影响因子：
3.2
通讯作者：
Xiao Shou-Jun
中科院分区：
文献类型：
--
作者：
Ali Mashooq;Afshan Noshin;Jiang Chuan;Xiao Shou-Jun
由线性寡核苷酸构建的用于构建DNA纳米结构的小DNA瓷砖在相对于DNA螺旋轴的横向方向上通常具有均匀的宽度。在这里，我们提供了一个例子，DNA哑铃形瓷砖在中央双螺旋茎和两个头环之间宽度不均匀，与辅助链相关联。DNA哑铃瓷砖的一个特点是，茎的长度控制着两个头部图案的立体结构。位于11bp的茎将哑铃形瓷砖的两个头部图案扭曲成平行的构象，而位于16bp的茎将两个头部图案扭曲成反平行的构象。我们成功地构建了四个DNA哑铃形瓷砖，并将它们组装成具有斑马状图案的平面纳米带和精细纳米管的二维(2D)阵列。
Small DNA tiles built from linear oligonucleotides for the construction of DNA nanostructures often have even widths in the lateral direction against the DNA helical axis. Herein we present an example of DNA dumbbell tiles with uneven widths between the central double helical stem and the two head loops after association with helper strands. A characteristic of DNA dumbbell tiles is that the stem length controls the stereostructure of the two head motifs. A stem at 11 bp twists two head motifs of a dumbbell tile into parallel conformations, wheareas a stem at 16 bp twists two head motifs into antiparallel conformations. We successfully constructed four DNA dumbbell tiles and assembled them into two-dimensional (2D) arrays of planar nanoribbons with zebra-like patterns and fine nanotubes as well.