Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases.
Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases.
复制标题
miR-17-92 簇在心血管发育和常见疾病中的作用。
DOI：
10.1155/2017/9102909
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发表时间：
2017
影响因子：
--
通讯作者：
Zhou L
中科院分区：
文献类型：
--
作者：
Gu H;Liu Z;Zhou L
microRNA（miRNAs和miRs）是一类非编码的单链小RNA分子。精确调控它们的表达对于维持组织内环境的稳定和生物体的正常发育是必不可少的。因此，miRNA的不平衡表达是许多疾病的标志。两个到几十个miRNA可以形成一个miRNA簇，miR-17-92簇就是其中之一。尽管miR-17-92簇最初被描述为致癌的miRNA簇，但也已发现其在正常心脏发育和心血管疾病中起关键作用。本文就miR-17-92簇在心脏中的特性和功能作一综述。
MicroRNAs (miRNAs and miRs) are a large class of noncoding, single-stranded, small RNA molecules. The precise control of their expression is essential for keeping tissue homeostasis and normal development of organisms. Thus, unbalanced expression of miRNAs is a hallmark of many diseases. Two to dozens of miRNAs can form into a miRNA cluster, and the miR-17-92 cluster is one of them. Although firstly described as an oncogenic miRNA cluster, the miR-17-92 cluster has also been found to play critical role in normal cardiac development and cardiovascular disease. This review focuses on the characteristics and functions of miR-17-92 cluster in heart.