Target selection for structural genomics
Target selection for structural genomics
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DOI：
10.1038/80747
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发表时间：
2000-11-01
期刊：
影响因子：
--
通讯作者：
Brenner, SE
中科院分区：
文献类型：
--
作者：
Brenner, SE
结构基因组学的目标是使用高通量结构确定和计算分析来提供每一种易处理蛋白质的三维模型。选择蛋白质进行实验结构表征的过程称为靶标选择。在这个命名法中，目标是要用结晶学或核磁共振研究的蛋白质区域。靶标的选择主要是一个计算过程，将候选蛋白质限制在那些易于处理和结构未知的蛋白质中，并根据预期的兴趣和可获得性进行优先排序。
Structural genomics aims to use high-throughput structure determination and computational analysis to provide three-dimensional models of every tractable protein. The process of choosing proteins for experimental structure characterization is known as target selection. In this nomenclature, the targets are regions of proteins to be studied by crystallography or NMR. Selection of the targets is principally a computational process of restricting candidate proteins to those that are tractable and of unknown structure, and prioritizing according to expected interest and accessibility.