Role of Sam68 in post-transcriptional gene regulation.
Role of Sam68 in post-transcriptional gene regulation.
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DOI：
10.3390/ijms141223402
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发表时间：
2013-11-28
影响因子：
5.6
通讯作者：
Sánchez-Margalet V
中科院分区：
文献类型：
--
作者：
Sánchez-Jiménez F;Sánchez-Margalet V
蛋白质的星星家族将信号传导途径与RNA的转录后调节和加工的各个方面联系起来。Sam68属于这类异源核糖核蛋白颗粒K（hnRNP K）同源性（KH）单结构域RNA结合蛋白家族，该家族还包含一些预测结合信号转导途径中的关键组分的结构域。响应于磷酸化和其他转录后修饰，Sam68已被证明具有将信号转导途径与调节RNA代谢的下游效应（包括转录、选择性剪接或RNA转运）联系起来的能力。除了在一些信号通路中作为对接蛋白的功能外，这种原型星星蛋白已被鉴定为具有核定位并且参与核和胞质多分子复合物如Sam68核体和应激颗粒的形成。Sam68与其他蛋白质和RNA靶点偶联，可根据内外信号在差异表达和mRNA加工和翻译的调节中发挥作用，从而介导重要的生理功能，如细胞死亡、增殖或细胞分化。
The STAR family of proteins links signaling pathways to various aspects of post-transcriptional regulation and processing of RNAs. Sam68 belongs to this class of heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) single domain-containing family of RNA-binding proteins that also contains some domains predicted to bind critical components in signal transduction pathways. In response to phosphorylation and other post-transcriptional modifications, Sam68 has been shown to have the ability to link signal transduction pathways to downstream effects regulating RNA metabolism, including transcription, alternative splicing or RNA transport. In addition to its function as a docking protein in some signaling pathways, this prototypic STAR protein has been identified to have a nuclear localization and to take part in the formation of both nuclear and cytosolic multi-molecular complexes such as Sam68 nuclear bodies and stress granules. Coupling with other proteins and RNA targets, Sam68 may play a role in the regulation of differential expression and mRNA processing and translation according to internal and external signals, thus mediating important physiological functions, such as cell death, proliferation or cell differentiation.
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