Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico
Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico
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DOI：
10.1073/pnas.0903045106
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发表时间：
2009-05-26
影响因子：
11.1
通讯作者：
Jimenez-Sanchez, Gerardo
中科院分区：
文献类型：
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作者：
Silva-Zolezzi, Irma;Hidalgo-Miranda, Alfredo;Jimenez-Sanchez, Gerardo
墨西哥正在发展基因组医学的基础，以改善其人口的医疗保健。对不同群体的遗传多样性和连锁不平衡结构的广泛研究使人们有可能发展标记和归因策略来综合分析复杂疾病关联研究中常见的遗传变异。我们评估了墨西哥单倍型图谱的益处，以改进墨西哥人口中与常见疾病相关的基因识别。我们使用来自不同混合历史和特定种群动态的墨西哥Mestizos的全基因组数据来评估遗传多样性、连锁不平衡模式和单倍型共享程度。祖先是通过包括1个墨西哥美洲印第安人群体和来自HapMap的数据进行评估的。我们的结果提供了墨西哥亚群之间遗传差异的证据，在设计和分析复杂疾病的关联研究时应该考虑这些差异。此外，这些结果支持这样的观点，即墨西哥Mestizo群体的单倍型图谱可以减少表征该群体常见遗传变异所需的标签SNPs的数量。这是拉丁美洲最近混血人群的第一次全基因组基因分型工作之一。
Mexico is developing the basis for genomic medicine to improve healthcare of its population. The extensive study of genetic diversity and linkage disequilibrium structure of different populations has made it possible to develop tagging and imputation strategies to comprehensively analyze common genetic variation in association studies of complex diseases. We assessed the benefit of a Mexican haplotype map to improve identification of genes related to common diseases in the Mexican population. We evaluated genetic diversity, linkage disequilibrium patterns, and extent of haplotype sharing using genomewide data from Mexican Mestizos from regions with different histories of admixture and particular population dynamics. Ancestry was evaluated by including 1 Mexican Amerindian group and data from the HapMap. Our results provide evidence of genetic differences between Mexican subpopulations that should be considered in the design and analysis of association studies of complex diseases. In addition, these results support the notion that a haplotype map of the Mexican Mestizo population can reduce the number of tag SNPs required to characterize common genetic variation in this population. This is one of the first genomewide genotyping efforts of a recently admixed population in Latin America.