Preexposure prophylaxis and predicted condom use among high-risk men who have sex with men.
Preexposure prophylaxis and predicted condom use among high-risk men who have sex with men.
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DOI：
10.1097/qai.0b013e3181e19a54
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Parsons JT
中科院分区：
文献类型：
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作者：
Golub SA;Kowalczyk W;Weinberger CL;Parsons JT
暴露前预防（PREP）是一种新兴的艾滋病毒预防策略；然而，许多人担心，这可能导致忽视通过行为解除抑制或风险补偿来减少风险的传统做法。在2007年9月至2009年7月期间，180名hiv阴性的高危男性在纽约市被招募，他们完成了一项音频计算机辅助自我访谈管理的调查。使用双变量和多变量逻辑回归模型来预测使用PREP的意图和PREP会减少安全套使用的看法。几乎70% （n = 124）的参与者报告说，如果预防艾滋病毒的有效性至少为80%，他们可能会使用PREP。在那些使用PREP的人中，超过35%的人报告说他们在使用PREP时可能会减少安全套的使用。在多变量分析中，使用安全套的性兴奋/快感障碍显著预测使用PREP的可能性（优势比= 1.71,P < 0.05），使用安全套的风险感知动机显著预测使用PREP的安全套的可能性（优势比= 2.48,P < 0.05）。这些数据为行为去抑制和风险补偿模型提供了支持，并强调了在向高风险人群大规模提供PREP的同时，制定行为干预措施的重要性。
Preexposure prophylaxis (PREP) is an emerging HIV prevention strategy; however, many fear it may lead to neglect of traditional risk reduction practices through behavioral disinhibition or risk compensation. Participants were 180 HIV-negative high-risk men who have sex with men recruited in New York City, who completed an Audio Computer Assisted Self Interview-administered survey between September 2007 and July 2009. Bivariate and multivariate logistic regression models were used to predict intention to use PREP and perceptions that PREP would decrease condom use. Almost 70% (n = 124) of participants reported that they would be likely to use PREP if it were at least 80% effective in preventing HIV. Of those who would use PREP, over 35% reported that they would be likely to decrease condom use while on PREP. In multivariate analyses, arousal/pleasure barriers to condom use significantly predicted likelihood of PREP use (odds ratio = 1.71, P < 0.05) and risk perception motivations for condom use significantly predicted decreased condom use on PREP (odds ratio = 2.48, P < 0.05). These data provide support for both behavioral disinhibition and risk compensation models and underscore the importance of developing behavioral interventions to accompany any wide-scale provision of PREP to high-risk populations.