Why Most Gene Expression Signatures of Tumors Have Not Been Useful in the Clinic
Why Most Gene Expression Signatures of Tumors Have Not Been Useful in the Clinic
复制标题
DOI：
10.1126/scitranslmed.3000313
复制
发表时间：
2010-01-13
影响因子：
17.1
通讯作者：
Koscielny, Serge
中科院分区：
文献类型：
--
作者：
Koscielny, Serge
组学技术有望增强我们对各种疾病的理解，并为患者特定的个性化医疗打开大门。尽管有大量关于使用基因表达阵列预测癌症患者预后的文献，但在用于临床的基因表达标签的翻译方面进展甚微。乳腺癌提供了一个成熟的竞技场来分析为什么这些签名未能实现他们的承诺。
Omics technologies are expected to enhance our understanding of a variety of diseases and to open the door to patient-specific personalized medicine. Despite the extensive literature on the use of gene expression arrays to predict prognosis in cancer patients, poor progress has been made in the translation of gene expression signatures for use in the clinics. Breast cancer provides a ripe arena for an analysis of why such signatures have failed to fulfill their promise.