Tumor growth fraction in cervical carcinoma.
Tumor growth fraction in cervical carcinoma.
复制标题
宫颈癌中的肿瘤生长分数。
DOI：
10.1016/0090-8258(91)90085-j
复制
发表时间：
1991
影响因子：
4.7
通讯作者：
L. Mcguire
中科院分区：
文献类型：
--
作者：
W. Wong;L. Mcguire
用单克隆抗体Ki-67对31例宫颈癌进行了免疫化学研究，以确定肿瘤生长分数，Ki-67与仅由增殖细胞表达的核抗原反应。单个肿瘤的生长分数估计为1000个肿瘤细胞群体中染色细胞核的百分比。Ki-67检测的生长分数与有丝分裂指数和高组织学分级的宫颈癌有良好的相关性。本研究与D. C.布朗，D。科尔，K. C. Gatter和D. Y. Mason [Brit.J.Cancer57（2），178-181（1988）]显示Ki-67在评价宫颈癌中生长分数中的有用性。
Thirty-one cervical carcinomas have been studied immunohistochemically to determine tumor growth fraction by using the monoclonal antibody Ki-67, which reacts with a nuclear antigen expressed only by proliferating cells. The growth fraction of individual tumor is estimated as the percentage of stained nuclei in a population of 1000 tumor cells. There is a good correlation of the growth fraction measured by Ki-67 with mitotic index and high histological grade of cervical carcinoma. This study, together with that of D. C. Brown, D. Cole, K. C. Gatter, and D. Y. Mason [Brit. J. Cancer57(2), 178–181 (1988)], shows the usefulness of Ki-67 in the evaluation of growth fraction in cervical carcinoma.