Folic acid supplement use and the risk of gestational hypertension and preeclampsia
Folic acid supplement use and the risk of gestational hypertension and preeclampsia
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DOI：
10.1016/j.wombi.2017.08.128
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发表时间：
2018-04-01
期刊：
影响因子：
3.8
通讯作者：
Chambers, Christina D.
中科院分区：
文献类型：
--
作者：
De Ocampo, Maria P. G.;Araneta, Maria Rosario G.;Chambers, Christina D.
背景：妊娠期高血压疾病是孕产妇发病和死亡的主要原因之一。研究表明，叶酸的使用可能会降低妊娠期高血压疾病的风险。目的：本研究的目的是评估含叶酸补充剂使用的时间和持续时间对妊娠期高血压和先兆子痫风险的影响。方法：暴露和结果数据是通过采访和审查来自美国MotherToBaby队列研究的参与者的医疗记录获得的和加拿大人口统计学、病史、生活方式因素、药物使用和胎儿性别被评估为潜在混杂因素。采用比值比和95%可信区间对未校正和校正的妊娠期高血压和先兆子痫风险进行了研究。与不使用补充剂相比，早期和晚期使用补充剂与妊娠高血压或先兆子痫的发生无显著相关性。发展妊娠期高血压和先兆子痫的几率显着降低的持续时间含叶酸的补充剂useingincreased.Conclusion：这项研究的结果表明，使用含叶酸的补充剂可能会减轻妊娠期高血压和先兆子痫的风险。(C)2017年澳大利亚助产士学院。由爱思唯尔有限公司出版。保留所有权利。
Background: Hypertensive disorders of pregnancy are among the leading causes of maternal morbidity and mortality. Studies suggest that the use of folic acid may lower the risk of hypertensive disorders in pregnant women.Aim: The aim of this study was to assess the effects of timing and duration of folic acid-containing supplement use on the risk for gestational hypertension and preeclampsia.Methods: Exposures and outcomes data were obtained through interviews and review of participant's medical records from the MotherToBaby cohort studies across the United States and Canada. Demographics, medical history, lifestyle factors, substance use, and fetal sex were assessed as potential confounders. Unadjusted and adjusted risks for gestational hypertension and preeclampsia were examined using odds ratios and 95% confidence intervals.Findings: 3247 women were included in the study. Compared to non-supplement use, early and late supplement use were not significantly associated with the development of gestational hypertension or preeclampsia. The odds of developing gestational hypertension and preeclampsia were significantly reduced as the duration of folic acid-containing supplement use increased.Conclusion: Findings from this study suggest that the use of folic acid-containing supplements may mitigate the risk for gestational hypertension and preeclampsia. (C) 2017 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.