First total synthesis of antiostatin A1, a potent carbazole-based naturally occurring antioxidant
First total synthesis of antiostatin A1, a potent carbazole-based naturally occurring antioxidant
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DOI：
10.1039/b820291e
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发表时间：
2009-01-01
影响因子：
4.9
通讯作者：
Witulski, Bernhard
中科院分区：
文献类型：
--
作者：
Alayrac, Carole;Schollmeyer, Dieter;Witulski, Bernhard
报道了强效抗氧化剂抗骨抑素A（1）的首次全合成，其中其关键特征依赖于使用官能化的双酰胺的化学和区域选择性铑催化的交叉炔环三聚反应和钯催化的芳基酰胺化反应。
The first total synthesis of the potent antioxidant antiostatin A(1) is reported, where its key features rely on a chemo- and regioselective rhodium-catalysed crossed alkyne cyclotrimerisation reaction applying functionalised ynamides and a palladium-catalysed arylamidation reaction.